大剂量硫酸镁对颅脑创伤后神经功能影响的实验研究  

Effect of Magnesium on Neurological Outcome Following Traumatic Brain Injury in Rats

作　　者：鲁晓杰[1] 刘道坤[2] 黄长铭[1] 陆岩 

机构地区：[1]无锡市第二人民医院脑外科,无锡214002 [2]南通医学院附属医院脑外科

出　　处：《苏州医学院学报》2000年第1期32-33,53,共3页Acta Academiae Medicinae Suzhou

摘　　要：目的　了解创伤性脑损伤（ｔｒａｕｍａｔｉｃ ｂｒａｉｎ ｉｎｊｕｒｙ，ＴＢＩ） 后大剂量硫酸镁对伤后神经功能的保护作用。方法　ＳＤ 大鼠１０ 只随机分为损伤组及治疗组（伤后３０ｍｉｎ／ＭｇＳＯ４ ，６００ｍｇ／ｋｇ 皮下注射） 。采用Ｆｅｅｎｅｙ 自由落体撞击法造成ＴＢＩ模型，伤后１６８ｈ 处死。分别对损伤组及治疗组伤后１ 周内进行了神经功能预后评价。结果　治疗组较损伤组神经功能明显改善（Ｐ＜ ０．０１） 。结论　大剂量ＭｇＳＯ４ 对大鼠ＴＢＩ后神经功能具有显著保护作用，具有临床应用价值。Objective To determine and evaluate the effect of the postinjury treatment of large dose MgSO 4 on neurological deficits following experimental traumatic brain injury (TBI) in rats.Methods Ten SD rats were randomly devided into two experimental groups:TBI and TBI with MgSO 4 were subcutaneously 30 minutes after.Cerebral contusion was produced by dropping weight.Beam-walking and beam-balance were measured to evaluate neurological function within seven days after injury.Results The neurological function of rats of the MgSO 4-ad-ministered improved significantly in the 168h hour compared to that of the untreated rats ( P <0.01).Conclusions This study suggests that postinjury treatment with large-dose of MgSO 4 improve neurological outcome after experimental TBI,which might have clinical value for treating human brain injury.

关 键 词：大鼠 硫酸镁 神经功能 颅脑损伤 

分 类 号：R651.15[医药卫生—外科学]