铁屎米酮对实验性心律失常的作用  

Effect of Canthin-6-one on Experimental Arrhythmia

作　　者：石明建 刘惟莞[1] 王红英[1] 程虹 胡岚 

机构地区：[1]湖北医科大学药理学教研室,武汉430071 [2]湖北医科大学附一院麻醉科

出　　处：《中草药》2000年第1期37-39,共3页Chinese Traditional and Herbal Drugs

摘　　要：铁屎米酮 5 ,10 ,2 0 m g/ kg ig可明显提高乌头碱致大鼠、哇巴因致豚鼠发生室性早博、室性心动过速、室颤的用量 ;降低大鼠缺血再灌性室性心律失常发生率 ,缩短心律失常持续时间 ,防止室颤的发生。Effect of canthin 6 one (Can)(an alkaloid extracted from Zanthoxylum dimorphophylhum Hemsl. var. spinifolium Rehd. et Wils.) on experimental arrhythmia induced by aconitine, ouabain and ischemia/reperfusion was studied. Can (5, 10, 20 mg/kg, ig) was shown to increase the threshold dose of causing ventricular ectopic, ventricular tachycardia, ventricular fibrillation; decrease the incidence of arrhythmia induced by ischemia/reperfusion, shorten duration of ventricular arrhythmia and eliminate the incidence of ventricular fibrillation. These results suggested that canthin 6 one has a protective effect on experimental arrhythmia.

关 键 词：铁屎米酮 心律失常 大鼠 中医药疗法 

分 类 号：R259.417[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]