Synthesis and Crystal Structure of Monocarbonyl Analogs of Curcumin  

作　　者：赵承光 陈小燕 胡杰 张丽 赵云洁 杨树林 梁广 

机构地区：[1]School of Pharmacy,Wenzhou Medical College [2]Institute of Biotechnology,Nanjing University of Science and Technology [3]The First Affiliated Hospital,Wenzhou Medical College

出　　处：《Chinese Journal of Structural Chemistry》2012年第4期491-498,共8页结构化学（英文）

基　　金：supported by the National Natural Science Foundation of China (21102106);Project of Wenzhou Sci&Tech Bureau (Y20100273 and Y20100006);Natural Science Foundation of Zhejiang Province (Y4110197 and Y2101108)

摘　　要：Two monocarbonyl analogs of curcumin containing bis（2,6-difluorobenzyl） were synthesized,and their molecular structures were characterized by 1H NMR,ESI-MS,and X-ray crystallography.In this paper,the crystal structures of these two analogs（A75 and C75） are described and compared with their bis（2-fluorobenzyl） analogues as well as with the available data of curcumin.The cyclopentane rings in A75 have an envelope conformation,while the cyclohexane ring in C75 has a chair conformation.The compounds are symmetrical and the central structure of A75 and C75 connects with two benzylidene rings through E,E-oriented double bonding.Two monocarbonyl analogs of curcumin containing bis（2,6-difluorobenzyl） were synthesized,and their molecular structures were characterized by 1H NMR,ESI-MS,and X-ray crystallography.In this paper,the crystal structures of these two analogs（A75 and C75） are described and compared with their bis（2-fluorobenzyl） analogues as well as with the available data of curcumin.The cyclopentane rings in A75 have an envelope conformation,while the cyclohexane ring in C75 has a chair conformation.The compounds are symmetrical and the central structure of A75 and C75 connects with two benzylidene rings through E,E-oriented double bonding.

关 键 词：bis（2 6-difluorobenzyl） X-ray crystallography mono-carbonyl analogues of curcumincurcumin 

分 类 号：O621.2[理学—有机化学]