体外血液循环中切变率对生物材料血液相容性的影响  

IN VITRO EFFDCT OF SHEAR RATE ON HEMOCOMPATIBILITYOF BIOMATERIALS IN BLOOD CIRCULATION

作　　者：张京川[1] 奚廷斐[1] 杨子彬[2] 

机构地区：[1]中国药品生物制品检定所 [2]中国医学科学院

出　　处：《中国生物医学工程学报》1990年第4期270-276,共7页Chinese Journal of Biomedical Engineering

摘　　要：本文报告了在体外血液循环中切变率50～4,000s^(-1)范围内对三种管径相同的生物材料表面与血液相互作用后的测定结果。作者采用^(125)I标记的抗人血小板单克隆抗体(SZ-21)测定血小板粘附数量及用“凝血自动分析仪”测定了反映内源性凝血因子激活的变化。 本研究发现,在生理切变宰范围内的血液参数变化并不与切变率的增加成正比,而是存在着两个使生物材料血液相容性指标发生突变的“临界切变率”,当切变率超过2,500s^(-1)后产生血液参数的病理学改变。<ABSTRACT> The thesis reports results of human blood interaction with surfaces of Albumin, Silicone and Polyethylene in range of shear rate from 50 to 4,000s-1. After 5 min perfusion in vitro with fresh ACD anticoagulated whole blood at 50-4,000-1, platelets deposition on surfaces of biomaterials were deter- mined using monoclona1 antibodies to human platelet membrance g1ycoprotein SZ-21. Simultaneously, PTT (Partical Thromboplastin Time ), which indi- cate activity of coagulation factors in blood, was detemined with the AUTO- Fi Coagulation Instrument. The results show that the change of hemocomp- atibility index is mostly out of proportion to the in crease of shear rate with in physiological range, except for two Critical points of shear rate (50-200s-1 and 2,000-2,500s-1 ) causing sudden rise of evaluated indexes.

关 键 词：体外血液循环 生物材料 血液相容性 

分 类 号：R318.08[医药卫生—生物医学工程]