2009-2010年金瑞镇暴露者狂犬病疫苗接种反应及免疫效果观察  

Observation the vaccination reaction and immune effect of rabies exposed people in Jinrui town during 2009 to 2010

作　　者：袁和根 刘莉红[2] 

机构地区：[1]宜春市袁州区金瑞镇防保站,江西336000 [2]宜春市疾病预防控制中心

出　　处：《医学动物防制》2012年第4期375-377,共3页Journal of Medical Pest Control

摘　　要：目的观察人用狂犬病疫苗的接种反应及免疫效果。方法对金瑞镇2009-2010年狂犬病疫苗(全程5针)免疫者观察其接种反应并用间接ELISA法检测狂犬病毒抗体。被检对象分为<15岁组、15～30岁组、31～60岁组和>61岁组。结果共接种狂犬疫苗609例,免疫后抗体阳性587例,阳性率为96.39%。年龄越小抗体阳性率越高,差异均有统计学意义(P<0.01);女性与男性抗体阳性率差异无统计学意义;不同产地疫苗间的抗体阳性率差异无统计学意义(P>0.05)。结论人用狂犬病疫苗有良好的安全性及免疫原性,但对免疫失败者应加强免疫。Objective To understand the vaccination reaction and immunization effect of human rabies vaccine.Method Observation the vaccination reaction of rabies exposed people who accepted full course（five doses） of rabies vaccine and their antibody against rabies virus was detected by ELISA.The subjects were divided into four groups,less than 15 years old group,15 and 30 years group,31 and 60 years group and above 61 years old group.Results Total of 609 persons were inoculation rabies vaccines,587 cases were antibody positive,the positive rate was 96.39 %（587/609）.There was no statistically significant between male antibody rate to female.With the age increasing,the positive rates decreased（P〈 0.01）.The antibody positive rates of different kinds of rabies vaccines had no significant different（P〉0.05）.Conclusions Rabies vaccine showed good safety and immunogenicity,but it need to reinforce to the people who＇s antibody was negative.

关 键 词：狂犬病疫苗 狂犬病毒抗体 安全性 免疫原性 

分 类 号：R186[医药卫生—流行病学]