胞外钙调素对大鼠创面愈合的作用研究  

Efficacy of extracellular calmodulin on rats wound healing

作　　者：甘露[1] 高东旗[1] 张庆华[2] 宋文静[1] 张玉国[1] 

机构地区：[1]北京军区疾病预防控制中心,北京100042 [2]白求恩国际和平医院

出　　处：《医学动物防制》2012年第4期406-407,共2页Journal of Medical Pest Control

摘　　要：目的研究胞外钙调素对大鼠创伤的促愈合作用。方法建立大鼠背部刀割伤模型,用创面照像、透明膜描记扫描记录伤后第4、8、12、16d的创面面积。结果实验组愈合时间为13.5d,对照组愈合时间为15.8d,创伤愈合时间明显缩短（P〈0.05）。结论显示胞外钙调素具有促进大鼠皮肤创伤愈合的作用,其作用机理可能与促进细胞增殖、分裂有关。Objective To study the effect of extracellular calmodulin on rats wound healing.Method Establishing a rat model with back incised wound,using photographically,hyaline membrane tracing to scannogram the area of wound surfaces of 4,8,12th days.Results The healing time of experimental group was 13.5d,control group was 15.8d,the healing time was significantly shorter（P〈0.05）.Conclusions Extracellular calmodulin had effect on skin wound healing.The mechanism of action was relation to cells proliferation and cleavage.

关 键 词：胞外钙调素 创伤模型 创伤愈合 

分 类 号：R641[医药卫生—外科学] R332[医药卫生—临床医学]