C-反应蛋白、纤维蛋白原和脂蛋白(a)联合检测在冠心病诊断中的应用  

Value of C-reactive protein,fibrinogen and lipoprotein(a) in diagnosis of coronary heart disease

作　　者：刘超[1] 吴月平[1] 倪杰[2] 

机构地区：[1]江苏省南通市第三人民医院检验科,南通226006 [2]江苏省南通市第三人民医院心内科,南通226006

出　　处：《南通大学学报（医学版）》2012年第2期134-136,共3页Journal of Nantong University(Medical sciences)

摘　　要：目的:分析C-反应蛋白(CRP)、纤维蛋白原(Fib)、脂蛋白(a)[Lp(a)]联合检测在冠心病(CHD)诊断中的价值。方法:对96例临床症状符合但并未确诊为CHD的患者进行冠状动脉造影,根据造影结果分为CHD组和非CHD组,并选取健康体检者作为对照组,进行CRP、Fib、Lp(a)的检测,对结果进行分析与讨论。结果:CHD组CRP、Fib、Lp(a)的检测结果明显高于非CHD组(P<0.05)和对照组(P<0.01),并且联合检测3项指标诊断的特异度高于单独检测。结论:联合检测CRP、Fib、Lp(a)有助于CHD的预测与诊断。Objective： To study the value of detecting C-reactive protein（CRP）,fibrinogen（Fib） and lipoprotein（a） in the diagnosis of coronary heart disease（CHD）.Methods： 96 undiagnosed cases of CHD undergone coronary arteriongraphy were classified into CHD group and non-CHD group,and selected 100 healthy cases as control group,CRP,Fib and Lp（a） were evaluated and analyzed in all of these three groups.Results： The concentration of CRP,Fib and Lp（a） were significantly higher in CHD patients than that in the non-CHD subjects and control group（P0.01）.The specificity of detecting all the three markers was higher than that of single marker detecetion of either Lp（a） or Fig or CRP.Conclusion： Combined detection of three markers of CRP,Fib and Lp（a） may help improve the diagnosis of CHD.

关 键 词：冠状动脉粥样硬化性心脏病 C-反应蛋白 纤维蛋白原 脂蛋白(a) 

分 类 号：R541.4[医药卫生—心血管疾病]