参附注射液联用环磷腺苷葡胺治疗慢性充血性心力衰竭疗效观察  

Therapeutic Effects of Shenfu Injection with Meglumine Adenosine Cyclophsphupe Injection on Congestive Heart Failure

作　　者：张韶冈[1] 吴剑芸[1] 刘时彦[1] 黄为民[1] 王宇琴[1] 谭荣荣[1] 

机构地区：[1]广东省广州市第一人民医院

出　　处：《中西医结合心脑血管病杂志》2012年第4期391-392,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的观察参附注射液联合环磷腺苷葡胺(心先安)治疗充血性心力衰竭(CHF)的临床疗效。方法将68例CHF患者随机分为治疗组和对照组,各34例。对照组给予常规治疗,治疗组在常规治疗基础上联合应用参附注射液及心先安,以20d为1个疗程,测定治疗前后心功能指标:左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)和左室射血分数(LVEF),同时观察两组患者用药期间的不良反应。结果治疗组总有效率为91.18%,对照组为70.59%,两组比较差异有统计学意义(P<0.05)。两组治疗后心功能均有明显改善(P<0.05),但治疗组改善优于对照组(P<0.05)。两组均未发现明显不良反应。结论参附注射液联合心先安治疗CHF疗效优于常规治疗。Objective To observe the curative effect of Shenfu injection with Xinxian＇an injection on congestive heart failure.Methods Six-eight patients（pts） with congestive heart failure were randomly divided into two groups：Control group treated with routine treatment,and treatment group treated with Shenfu injection and Xinxian＇an injection on the basis of routine treatment for 20 days.The heart function index,left ventricular end-diastolic volume,left ventricular end-systolic volume and left ventricular ejection fraction were monitored before and after treatment and the adverse reaction was monitored.Results The total clinical effective rate was 91.18% in treatment group,which was significantly higher than that in control group（70.59%,P0.05）.The heart function index of both group were improved after treatment（P0.05）.Total effectiveness in treatment group was better than that in control group（P0.05）,There were no adverse reaction in both groups.Conclusion Shenfu injection with Xinxian＇an injection was obviously effective on congestive heart failure.

关 键 词：充血性心力衰竭 参附注射液 环磷腺苷葡胺 

分 类 号：R541.6[医药卫生—心血管疾病] R289.5[医药卫生—内科学]