正交试验优选丽安康片提取工艺  

Optimization of Extraction Process for Li'ankang Tablet by Orthogonal Test

作　　者：谭丽容[1,2] 梁海春[1,2] 吴典伟[1,2] 苏冀彦[1] 刘玮锦[1] 苏子仁[1,2] 

机构地区：[1]东莞广州中医药大学中医药数理工程研究院,广东东莞523808 [2]广州中医药大学中药学院新药开发研究中心,广州510006

出　　处：《中国实验方剂学杂志》2012年第9期20-22,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省2009年度国际合作项目(2009B050200004);广东省科技计划项目(2009A030100014)

摘　　要：目的:优选丽安康片提取工艺。方法:水提取部分以黄芪甲苷为指标,乙醇提取部分以淫羊藿苷为指标,分别采用正交试验优化提取工艺条件。结果:最佳提取工艺为黄芪、当归水提共煎,加8倍量水煎煮3次,每次1.5 h,70℃减压干燥;淫羊藿加14倍量70%乙醇提取2次,每次1 h。结论:优选的提取工艺合理、稳定、可行,可作为丽安康片的提取工艺。Objective：To optimize extraction process of Li＇ankang tablet.Method：Extraction process of Li＇ankang tablet was optimized by orthogonal design with multiple indexes.Astragaloside was used as index in water extract part,but with icariin as index in ethanol extract part.Result：Optimal extraction process of Li＇ankang tablet was as follows： ratio of Astragalus membranaceus and Angelica sinensis 5∶ 1,added 8 times the amount of water to boil together,decocted 3 times with 1.5 h each time,vacuum drying under 70 ℃;Epimedium brevicornu was added 14 times the amount of 70% ethanol to extract 2times,one h per time.Conclusion：Optimized extraction process of Li＇ankang tablet was reasonable,stable and feasible,and could be extraction technology of Li＇ankang tablet.

关 键 词：丽安康片 正交试验 提取工艺 高效液相色谱 

分 类 号：R283.6[医药卫生—中药学]