寒水石生品、炮制品在人工胃肠液中的溶出率  

Dissolution Rate of Raw and Processed Products of Gypsum Calcite in Artificial Intestinal Fluid and Gastric Juice

作　　者：陆景坤[1] 陈朝军[1] 周昊菲[1] 刘智杰[1] 毅和[1] 

机构地区：[1]内蒙古医学院药学院,呼和浩特010010

出　　处：《中国实验方剂学杂志》2012年第9期23-25,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：内蒙古自治区教育厅高等学校科学研究项目(NJ09110)

摘　　要：目的:对南、北寒水石奶淬、水淬、生品在人工胃肠液中溶出率进行分析。方法:通过人工模拟胃肠环境来分析寒水石的溶出情况,利用配位滴定法检测样品中主成分钙含量,计算溶出率。结果:南、北寒水石在人工胃液中溶出率在70%～110%,溶出率依次为奶淬<水淬<生品;在人工肠液中,南寒水石溶出率低于10%,其中生品溶出率最低,北寒水石低于20%,水淬制品溶出率最低。结论:南、北寒水石可能主要在胃内吸收,肠内吸收较少。Objective：To analyze dissolution ratio of milk quenching product,water quenching product and raw materials of Gypsum and Calcite in artificial intestinal fluid and gastric juice.Method：Dissolution rate of Calcium were analyzed in artificial gastrointestinal environment,to calculate dissolution ratio with detected the content of principal component（calcium） by coordination titration.Result：Dissolution ratio of Gypsum and Calcite in artificial gastric juice were between 70% and 110%,order of dissolution rate were：milk quenchingwater quenchingraw materials.In artificial intestinal fluid,dissolution rate of Calcite was less than 10%,dissolution ratio of raw materials was the lowest,while dissolution rate of Gypsum was less than 20%,the lowest one was water quenching products.Conclusion：Gypsum and Calcite might be mainly absorbed in stomach,and it was lower in the intestinal.

关 键 词：寒水石 炮制 人工胃肠液 溶出率 

分 类 号：R283.6[医药卫生—中药学]