冰片促进口服药物吸收的研究  

Effect of Borneol on Promoting Absorption of Oral Drugs

作　　者：张海燕[1,2] 邬伟魁[1] 芦乾[1] 贺娅[1] 宋伟[1] 李芳[1] 杨明[1,3] 

机构地区：[1]江西中医学院现代中药制剂教育部重点实验室,南昌330004 [2]西南交通大学材料先进技术教育部重点实验室,成都610003 [3]成都中医药大学,成都611137

出　　处：《中国实验方剂学杂志》2012年第9期294-297,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：重大新药创制重大专项(2009ZX09103-393);"十一五"重大新药创制项目(2009ZX09310-005);中医药行业科研专项项目(200708006)

摘　　要：对冰片促进口服药物吸收的实验研究进行文献整理和分析。生物利用度低是口服药物制剂经常出现的情况,选用安全有效的吸收促进剂来增加口服药物的生物利用度的研究方兴未艾。对冰片促进口服药物吸收作用的3种研究方法(在体法、体外法和体内法)的文献报道进行综述并加以探讨,分析认为,冰片对口服药物吸收的调节作用与药物分子结构和给药浓度,冰片的种类、浓度和用法等存在一定的关系,但吸收机制尚未明确。故针对水溶性差和代谢迅速的药物生物利用度低的问题,冰片促进口服药物吸收的研究将为冰片促吸收的深入研究提供一定的参考。Literatures about promoting absorption of oral drugs by borneol are analyzed.It is usual that the oral bioavailability is poor.Appling a safe and effective absorption enhancer to increase oral bioavailability is becoming a focus.This paper mainly reviews three methods about promoting absorption of oral drugs（in situ,in vitro and in vivo）.Research showed that the effect of borneol on regulating the absorption of oral drugs was related to the drug structure and concentration,species,concentration and usage of borneol,but the mechanism of absorption is uncertain.Therefore,for the drugs of poor bioavailability of poor solubility and rapid metabolism,the development status of borneol will provide references for further research on borneol promoting absorption.

关 键 词：冰片 肠吸收 口服 鼻腔给药 吸收促进剂 

分 类 号：R283[医药卫生—中药学]