基于动脉管壁的脂联素球状域保护机理  

Protective mechanism of globular adiponectin based on arteral wall

作　　者：王平平[1] 尹卫东[1] 

机构地区：[1]南华大学心血管病研究所,衡阳421001

出　　处：《生命的化学》2012年第2期127-130,共4页Chemistry of Life

摘　　要：脂肪细胞分泌产物脂联素(adiponectin,APN)的发现是脂肪内分泌学研究领域的重大进展。它主要通过与相应受体结合,发挥相应的生物学效应,且其心血管保护作用目前已成为研究热点。动脉管壁上也存在其受体,在此基础上,将APN活性区域的脂联素球状域(globular domain of adiponectin,gAd)设计为新靶点,研究其对动脉管壁的保护作用及其相关机理,将为动脉粥样硬化疾病的防治提供新方案。Adiponectin is a protein secreted exclusively by white adipose tissue and is abundantly present in human plasma.It has essential biological effects,and its protective effects on arteral wall have become a research hotspot.The globular domain of adiponectin is considered to be bioactive.It is a new target for studying the protective mechanism for vascular wall,which may have great significance in the preventive and therapeutic strategies of atherosclerosis.

关 键 词：脂联素球状域 脂联素受体 保护机理 动脉管壁 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]