多囊卵巢综合征患者一级亲属代谢表型及心血管疾病风险的分析  

Metabolic phenotype and cardiovascular risk factors in the first degree relatives of Chinese women with polycystic ovary syndrome

作　　者：陶弢[1] 刘伟[1] 赵爱民[2] 毛秀英[1] 杨洁谨[1] 周佳雯[1] 

机构地区：[1]上海交通大学医学院附属仁济医院内分泌代谢科,200127 [2]上海交通大学医学院附属仁济医院妇产科,200127

出　　处：《中华内分泌代谢杂志》2012年第4期315-318,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：上海市科委重点科技攻关项目（08411953000）

摘　　要：为明确多囊卵巢综合征（PCOS）患者一级亲属的代谢表型改变及心血管疾病风险是否升高，比较110名PCOS患者一级亲属与年龄及体重相匹配的85名非PCOS正常女性一级亲属的代谢表型和心血管疾病风险的差异。PCOS患者一级亲属中母亲和父亲的糖耐量受损发生率分别是51．4％和57．5％。与非PCOS对照的一级亲属相比，PCOS患者一级亲属中空腹胰岛素水平、稳态模型评估的胰岛素抵抗指数、胰岛素曲线下面积及超敏C反应蛋白水平明显升高，而胰岛素敏感指数和高分子量脂联素水平明显降低（P〈O．05）。PCOS患者的一级亲属中除姐妹外，父母亲及兄弟的总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平明显高于正常对照组（P〈O．05）。PCOS患者一级亲属的代谢表型存在明显的胰岛素抵抗特征，即糖耐量受损、高脂血症、高炎症水平，提示其心血管疾病风险明显增高。To test the hypothesis that the first degree relatives of Chinese women with polycystic ovarian syndrome （PCOS） have higher risk of cardiovascular disease than those without PCOS. The metabolic phenotype and risks of cardiovascular disease were evaluated in 110 family members of 35 women with PCOS and 85 unrelated healthy control subjects without family history of diabetes and PCOS （four age- and weight-matched subgroups ）. The prevalence of impaired glucose tolerance was 51.4% in mothers and 57.5% in fathers with their daughters suffering from PCOS. The first degree relatives of PCOS women had significantly higher serum fasting insulin level, homeostasis model assessment for insulin resistance, insulin area under the curve, and lower insulin sensitivity index in all subgroups than the control subjects（ P〈O. 05 ）. The control subjects had significantly elevated high molecular weight- adiponectin levels and decreased high sensitive-C reactive protein levels compared to the first degree relatives of PCOS women in all subgroups. Parents and brothers, but not sisters, of women with PCOS had significantly higher total cholesterol and low density lipoprotein-cholesterol （ P〈0.05 ）, as well as triglyceride levels （ P〈0.05 ）, compared with control subjects. The first degree relatives of PCOS women had features of insulin resistance and increased risk of cardiovascular disease.

关 键 词：多囊卵巢综合征 一级亲属 胰岛素抵抗 心血管疾病 

分 类 号：R711.75[医药卫生—妇产科学]