脂联素对女性生殖内分泌影响的研究进展  

Progress of adiponectin in reproduction and fertility

作　　者：陶弢[1] 刘伟[1] 

机构地区：[1]上海交通大学医学院附属仁济医院内分泌代谢科,200127

出　　处：《中华内分泌代谢杂志》2012年第4期347-350,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：上海市科委重点科技攻关项目（08411953000）

摘　　要：证据提示脂联素在卵巢分泌类固醇激素和胎盘发育中发挥了重要的作用。其不仅直接影响晚期卵泡的合成，还影响胰岛素与促性腺激素释放激素作用从而影响初始卵泡形成。脂联素通过多种信号途径对卵巢功能和胎盘形成具有潜在性的作用，为代谢及生殖相关疾病的病因学研究和治疗提供新的思路。There is a strong support for a role played by adiponectin in the function of ovary and placenta. There is evidence of direct effects of adiponectin on the late stages of folliculogenesis, and additive interactions of adiponectin with insulin and gonadotropins in inducing periovulatory changes in ovarian follicles. Adiponectin has demonstrated a potential effect on ovarian function as well as a possible effect on the formation of placenta, via multiple mechanisms, providing new strategies for the etiology investigation, prevention and treatment of reproductive and related metabolic diseases.

关 键 词：脂联素 脂联素受体 信号途径 卵巢功能 多囊卵巢综合征 

分 类 号：R588[医药卫生—内分泌]