亚麻木酚素对去卵巢大鼠血脂水平的影响  

EFFECTS OF SECOISOLARICIRESINOL DIGLUCOSIDE ON BLOOD LIPIDS IN OVARIECTOMIZED RATS

作　　者：那晓琳[1] 赵新宇 李丽娜 张云波[1] 陈文华[1] 管春梅[1] 

机构地区：[1]哈尔滨医科大学公共卫生学院,哈尔滨150081 [2]哈尔滨市道里区妇幼保健站,哈尔滨150076 [3]浙江省上虞市疾病预防中心,上虞312300

出　　处：《营养学报》2012年第2期159-163,共5页Acta Nutrimenta Sinica

基　　金：黑龙江省教育厅科学技术研究项目(No.11531097)

摘　　要：目的研究亚麻木酚素(secoisolariciresinol diglucoside,SDG)对去卵巢大鼠血脂水平的影响。方法以8w龄雌性SD大鼠为研究对象,根据体重随机分为4组,分别为假手术组(SHAM)、去卵巢对照组(OVX)、低剂量和高剂量亚麻木酚素组(L-SDG、H-SDG)。手术后高脂饲料喂养1w,然后每日灌胃给予不同浓度的SDG。每2w取动物尾血分离血清测定血脂含量,喂养8w后处死大鼠,采集重要脏器称重并对子宫样本进行病理分析。结果与去卵巢对照组相比,高剂量的SDG(75mg/kg bw.d)对去卵巢引起的大鼠子宫萎缩有一定的抑制作用。SDG对去卵巢大鼠的肝脏、脾脏、双肾的脏体比均无显著影响(P>0.05),但能使大鼠的胸腺脏体比显著增加(P<0.05);显著升高血清高密度脂蛋白水平(P<0.05),对低密度脂蛋白没有影响(P>0.05),高剂量SDG可显著降低血清总胆固醇水平(P<0.05)。结论 SDG对高脂饲料喂养的去卵巢SD大鼠的子宫萎缩有一定的抑制作用并能增加胸腺重量,对血脂水平有一定的调节作用。Objective To observe the influence of secoisolariciresinol diglucoside（SDG） on serum lipid levels in ovariectomized rats.Methods Eight-week female SD rats were randomly divided into 4 groups according to their weight.After removing the ovaries（OVX） or performing sham operation,all rats were feed high-fat-diet for 1w and then the experimental groups were gived different concentrations of SDG for 8 w.Every 2 w,the blood was taken for measuring blood lipids.At the end of the experiment,all rats were sacrificed and the important organs were taken and weighed.The uterine samples were taken for pathology analysis.Results Compared with OVX control group,high-dose of SDG（75mg/kg bw d）could inhibit the uterine atrophy in a certain extent.There were no effects of SDG on liver,spleen and kidney index,but thymus-imdex was increased significantly（P0.05）.SDG could significantly increase HDL level（P0.05）,but LDL level was not changed（P0.05）.High-dose of SDG reduced the serum total cholesterol significantly（P0.05）.Conclusions SDG can inhibit uterus atrophy,increase thymus index and regulate rerum lipids in ovariectomized rats.

关 键 词：亚麻木酚素 体重 去卵巢大鼠 

分 类 号：R965[医药卫生—药理学]