三省(区)成人血脂异常与心血管病危险因素和心功能的相关性  

Correlation Between Blood Lipid Abnormality and Cardiovascular Risk Factors,Cardiac Function in Adults of Two Provinces and One Autonomous Region

作　　者：谢朝辉[1] 韩少梅[2,3] 齐保申[2,3] 徐成丽[2,3] 斯琴[2,3] 朱广瑾[2,3] 

机构地区：[1]北京电力医院,北京100035 [2]中国医学科学院基础医学研究所 [3]北京协和医学院基础学院

出　　处：《实用预防医学》2012年第4期488-492,共5页Practical Preventive Medicine

基　　金：国家科技部2002年社会公益研究专项资金重点项目(2002DIA10018)

摘　　要：目的通过描述中国三省（区）成人TC边缘升高、TG边缘升高、HDL-C减低和LDL-C边缘升高的分布特点,探讨血脂相关指标边缘升高或减低与心血管病危险因素和心功能的相关性,为成人健康管理提供理论依据。方法采用流行病学横断面的研究方法对中国河北省、浙江省和广西壮族自治区（三省区）18~74岁汉族成人的身体健康状况进行随机、分层、整群抽样问卷调查和体格检查。结果三省（区）成人总胆固醇边缘升高率为15.0%;甘油三酯边缘升高率为0.7%;高密度脂蛋白-胆固醇减低率为18.5%;低密度脂蛋白-胆固醇边缘升高率为9.5%。三省（区）TC边缘升高、TG边缘升高、HDL-C减低率、LDL-C边缘升高率与很多心血管病危险因素有关。多因素线性回归分析显示：TC边缘升高与年龄正相关。HDL-C减低与居住地农村、肥胖、农民职业负相关。多因素Logistic回归显示：TC边缘升高与年龄、初中正相关;居住地农村与TC边缘升高负相关。HDL-C减低与居住地农村、腰围、丧偶负相关。LDL-C边缘升高与年龄、文化程度初中、高中和大学正相关,与农民职业负相关。TC边缘升高组的CO、CI、SI、SV、LVET、SVR、LCW平均水平减少;高密度脂蛋白-胆固醇减低组CI、SV和LCW的平均水平减少（P〈0.05）;SI、SVR、LVET平均水平增加（P〈0.05）;低密度脂蛋白-胆固醇边缘升高组CI、SI平均水平减少（P〈0.05）;LCW、SVR、LVET、SV平均水平增加（P〈0.05）。结论我国三省（区）18~74岁成人血脂相关指标边缘升高或减低比例较高,与心血管病危险因素和心功能有关。对血脂相关指标边缘升高或减低成人进行健康管理具有重要的公共卫生意义。Objective To explore the correlation between the borderline high or low levels of blood lipids and cardiovascular risk factors,cardiac function based on analyzing the distribution of high-normal levels of TC,TG,LDL-C and low level of HDL-C in the adults of two provinces and one autonomous region in China,and to provide the theoretical evidence for adults＇ health management.Methods A cross-sectional epidemiological study was conducted among the adults aged 18-74 years in Hebei Province,Zhejiang Province and Guangxi Zhuang Autonomous Region of China.With a randomized,stratified and cluster sampling method,questionnaire surveys and health check-up were performed to investigate the health status of the adults.Results The incidence rates of high-normal levels of TC,TG,LDL-C and low level of HDL-C in the surveyed adults were 15.0%,0.7%,9.5% and 18.5%,respectively.The high-normal levels of TC,TG,LDL-C and low level of HDL-C were related to many cardiovascular risk factors.Multivariable linear regression analysis showed that the high-normal level of TC was positively related to age,while the low level of HDL-C was negatively correlated with living in rural areas,obesity,and peasant occupation.Multifactor Logistic regression analysis showed that the high-normal level of TC was positively related to age and educational background with junior middle school,while the high-normal level of TC was negatively correlated with living in rural areas.The low level of HDL-C was negatively related to living in rural areas,waist circumference,and the wid-owed.The high-normal level of LDL-C was positively correlated with age,educational backgrounds with junior or senior middle school and college degree,but negatively correlated with peasant occupation.The average levels of CO,CI,SI,SV,LVET,SVR and LCW in the group of high-normal TC level were decreased.The average levels of CI,SV and LCW in the group with low level of HDL-C were also reduced（P0.05）,while the average levels of SI,SVR and LVET were increased（P0.05）.The average l

关 键 词：TC边缘升高 TG边缘升高 HDL-C减低 LDL-C边缘升高 心血管病危险因素 心功能 相关性 健康管理 

分 类 号：R589.2[医药卫生—内分泌]