参麦注射液对重症急性胰腺炎患者血浆内皮素变化的影响  被引量:3

Effects of Shenmai injection on the expression of endothelin in patients with severe acute pancreatitis

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作  者:王卫军 张近波 方钱 李剑锋 金鹏飞 李智涛 侯建毅 

机构地区:[1]浙江省温岭市第一人民医院微创外科医学中心,317500 [2]浙江省温岭市第一人民医院急诊医学科,317500 [3]浙江省温岭市第一人民医院中心实验室,317500

出  处:《中华实验外科杂志》2012年第5期956-957,共2页Chinese Journal of Experimental Surgery

基  金:浙江省医学会临床科研基金资助项目(2009ZYC51)

摘  要:目的观察重症急性胰腺炎(SAP)患者血浆内皮素(ET)水平的变化特点及参麦对其影响。方法按照平行对照设计原理,将所有60名患者分为常规治疗组(A组)和常规治疗+参麦治疗组(B组)。对两组患者的相关临床资料及ET水平进行比较。结果与B组患者比较,A组患者第2天、第4天ET水平均明显升高[(80.36±11.05)比(98.18±11.83)、(93.63±8.59)比(107.53±9.26)](P均〈0.05);与B组患者比较,A组患者第7天ET水平明显升高(76.25±10.81比93.17±12.42)(P〈0.01);与B组患者比较,A组患者治疗前ET水平两组差异无统计学意义(P〉0.05);与B组患者比较,A组患者年龄、性别、APACHEⅡ评分等两组差异无统计学意义(P均〉0.05)。结论参麦注射液治疗SAP可有效降低患者血浆中的ET含量,通过改善SAP患者的微循环而起到较好的治疗作用。Objective To explore the changes of plasma endothelin (Err) as well as the effects of Shenmai in patients with severe acute pancreatitis (SAP). Methods Sixty patients with SAP were collected, and divided into routine treatment group ( group A) and Shenmai treatment group ( group B). The clinical data and ET levels were analyzed. Results The levels of ET were significantly higher in group A than those in group B at the day 2 and 4 [ (80. 36±11.05) vs (98. 18±11.83), and (93.63±8.59) vs (107. 53±9. 26)] (both P〈0. 05). The levels of ET were significantly higher in group A than those in group B at the clay 7 (76. 25±10. 81 vs 93.17±12.42, P 〈0. 01 ). There was no significant difference between group A and group B in age, gender, and APACHE Ⅱscore ( all P 〉 0. 05). Conclusion Shenmai injection can effectively reduce the plasma levels of ET in SAP patients, and exert its therapeutic effect through improving microciroulation of SAP patients.

关 键 词:重症急性胰腺炎 内皮素 参麦注射液 

分 类 号:R657.51[医药卫生—外科学]

 

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