新疆维、汉人群变应性鼻炎患者血清IL-4和IFN-γ水平及其与鼻粘膜嗜酸性粒细胞浸润的相关性  

The correlation between serum IL-4 and IFN-γ with nasal mucosa eosinophil infiltration in Xinjiang Uygur and Han population in patients with allergic rhinitis

作　　者：张清全 杨清[2] 孙勇 戴江红 姜孝芳 刘福太 娄重章 穆尼热 高丽 

机构地区：[1]新疆自治区地方病分子生物研究所XJDX0208,乌鲁木齐830054 [2]新疆医科大学第六附属医院呼吸内科,乌鲁木齐830000

出　　处：《中国免疫学杂志》2012年第4期355-356,361,共3页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(No.30560144);新疆维吾尔自治区自然科学基金(200821136);新疆维吾尔自治区高校科研计划项目(XJEDU2006141)

摘　　要：目的:探讨新疆维、汉人群变应性鼻炎(Allergic rhinitis,AR)患者血清白细胞介素4(Interleukin-4,IL-4)和干扰素γ(Interferon gamma,IFN-γ)水平与鼻粘膜嗜酸性粒细胞(Eosionphils,EOS)浸润的相关性。方法:采用酶联免疫吸附法(Enzyme-linked immunosorbnent assay,ELISA)测定59例维吾尔族AR患者、50例汉族AR患者外周血清IL-4和IFN-γ水平,高倍显微镜下观察病理涂片并计数AR患者鼻粘膜EOS计数。结果:维、汉人群AR患者血清IL-4和IFN-γ水平均无显著差异(t值分别为1.304和1.408,P均>0.05);维、汉人群AR患者IL-4水平与鼻粘膜嗜酸性粒细胞计数均呈正相关(r分别为0.828和0.691,P均<0.01),IFN-γ水平与鼻粘膜EOS计数均呈负相关(r分别为-0.712和-0.764,P均<0.01)。结论:维、汉人群AR患者的血清IL-4和IFN-γ水平均无显著差异,AR患者鼻粘膜EOS增多与血清IL-4分泌过多而IFN-γ分泌受抑制有关。Objective：To evaluate the correlation of serum IL-4 and IFN-γ level and nasal mucosa eosinophilic in Xinjiang Uygur,Han people allergic rhinitis patients.Methods：Through double-antibody Enzyme-linked Immunosorbent Assay（ELISA） 59 cases Uygur AR patients,50 patients Han＇s AR serum IL-4 and IFN-γ levels were analyzed,pathology smear was observed at high-power microscope and counting AR patients nasal smear eosinophil count.Results：There were not significantly different between Uygur and Han population of patients with allergic rhinitis serum IL-4 and IFN-γ levels（t values were 1.304 and 1.408,P0.05）,Uygur and Han IL-4 levels of AR patients and nasal eosinophil counts were positively correlated（r=0.828 and 0.691,P0.01）,IFN-γ levels and nasal eosinophil count was negatively correlated（r=-0.712 and-0.764,P0.01）.Conclusion：There were not significantly difference between Uygur and Han population of patients with allergic rhinitis serum IL-4 and IFN-γ levels.There were connection with excess secretion of serum IL-4 and inhibition secretion of IFN-γ and Uggur,Han peopeo allergic rhinitis nasal eosinophil counts.

关 键 词：鼻炎 变应性 白细胞介素4 干扰素Ⅱ型 嗜酸性粒细胞 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]