水溶性C_(60)-脱氢枞胺衍生物的合成及生物活性  

Synthesis and bioactivity study of water-soluble C_(60)-dehydroabietylamine derivatives

作　　者：范旭[1] 林中祥[1] 邓慧敏[2] 徐艳梅[1] 

机构地区：[1]南京林业大学化学工程学院,江苏南京210037 [2]中山大学仪器分析与研究中心,广东广州510275

出　　处：《南京林业大学学报（自然科学版）》2012年第2期29-34,共6页Journal of Nanjing Forestry University：Natural Sciences Edition

基　　金：国家自然科学基金项目(30871989);广东省自然科学基金项目(04009752)

摘　　要：以C60-脱氢枞胺吡咯烷衍生物和C60-脱氢枞胺氮烯加成物为原料,通过两种不同的水性化途径分别合成了两种水溶性的C60-脱氢枞胺富勒醇衍生物和两种水溶性的C60-脱氢枞胺甘氨酸衍生物。产物经TEM、FT-IR、ESI-MS、1H NMR和HPLC等分析方法检测确认为目标产物,且为加成度不同的混合物。对合成出的4种水溶性C60-脱氢枞胺衍生物进行了生物活性测试。结果表明,4种水溶性C60-脱氢枞胺衍生物对rTaq DNA聚合酶和HIV-1反转录酶均表现出一定的抑制作用,对卵巢癌细胞株几乎不表现出抑制活性。Two water-soluble C60-dehydroabietylamine fullerenol derivatives and two water-soluble glycine derivatives were synthesized by different water-borne modification method,with C60-dehydroabietylamine pyrrolidine derivative and nitrene addition derivative as the raw materials.The structures were characterized by TEM,FT-IR,ESI-MS,1H NMR and HPLC.The products were confirmed to be mixtures of components with different additional group numbers.These four derivatives were each given a bioactivity test.The results showed that they had different inhibition against both rTaq DNA polymerase and HIV-1 reverse transcriptase,while they showed less inhibition against the Hey 1B ovarian cancer cell line than HIV-1 reverse transcriptase.

关 键 词：水溶性C60-脱氢枞胺衍生物 HIV-1反转录酶 rTaq DNA聚合酶 生物活性 

分 类 号：TQ351[化学工程] O621[理学—有机化学]