糖尿病患者心脏舒张功能与动脉弹性功能的关系  

Relationship between heart diastolic function and pulse wave velocity in patients with diabetes mellitus.

作　　者：林晖莉[1] 余江水[1] 李美美[1] 林铮[1] 

机构地区：[1]福建医科大学附属第二医院心血管内科,泉州362000

出　　处：《中国综合临床》2012年第5期480-482,共3页Clinical Medicine of China

摘　　要：目的探讨2型糖尿病患者的心脏舒张功能和外周动脉脉搏波传导速度（PwV）之间的关系。方法选取55例2型糖尿病患者，进行心脏彩超、血清B型钠尿肽（BNP）和外周动脉的PWV的检测，根据超声、血清BNP检测结果分成舒张功能正常组33例和舒张功能不全组22例，另取30名健康者作为对照组，比较3组的PWV，并分析超声二尖瓣血流舒张早期峰值速度（E）与瓣环舒张早期峰值速度（E’）的比值（E／E’）与PWV、BNP与PWV的相关性。结果舒张功能不全的患者动脉PWV较其余两组明显增高[（770．00±82．11）、（1080．00±158．27）、（1780．00±288．44）cm／s，F=481．605，P〈0．05）。调整年龄、性别、血压和血脂后，相关性分析显示E／E’与PWV、BNP与PWV均呈正相关（r=0．58，P〈0．01；r=0．63，P〈0．05）。结论PWV可相应地反映2型糖尿病患者的心脏舒张功能，PWV可作为一种无创性临床指标提示早期舒张性心力衰竭的存在。Objective To evaluate the relationship between the heart diastolic function and pulse wave velocity in patients with diabetes mellitus. Methods Fifty-five patients with diabetes mellitus underwent echocardiogram exam, PWV, and BNP determination. Patients were divided into two groups according to the results ： the group with normal heart diastolic function （ n = 33 ） and the group with abnormal heart diastolic function （n = 22）. Another 30 healthy volunteers served as control group. The values of PWV were compared between the three groups. The relationship between E/E＇ and PWV, BNP and＇PWV were evaluated with correlation analysis. Results The PWV value of abnormal heart diastolic function group was significantly higher than that of other two groups. PWV was positively correlated with E/E＇and BNP （r =0. 58, P 〈0. 05;r = 0. 63, P 〈 0. 05）. Conclusion PWV is associated with the heart diastolic function. PWV can serve as an important factor to predict abnormal heart diastolic function in patients with diabetes mellitus.

关 键 词：脉搏波传导速度 糖尿病 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]