脯氨酸离子液体催化Knoevenagel缩合反应(英文)  

2-Pyrrolidinecarboxylic Acid Ionic Liquid Catalyzed Knoevenagel Condensation

作　　者：宋红兵[1] 于英豪[1] 陈学伟[1] 李雪辉[1] 奚红霞[1] 

机构地区：[1]华南理工大学化学与化工学院制浆造纸工程国家重点实验室,广东广州510640

出　　处：《催化学报》2012年第4期666-669,共4页

基　　金：supported by the National Natural Science Foundation of China(20876055 and 20906029);the Natural Science Foundation of Guangdong Province(S2011020001472);the Fundamental Research Funds for the Central Universities~~

摘　　要：改进了1-丁基-3-甲基咪唑L-脯氨酸([bmim][Pro])功能化离子液体的合成路线,并将该离子液体用于催化含活泼亚甲基化合物与醛或酮的Knoevenagel缩合反应.在水介质中,室温下,该离子液体可快速催化上述Knoevenagel缩合反应,并选择性生成α,β-不饱和羰基化合物且分离收率可达到88%～97%.该脯氨酸离子液体循环重复使用6次后,催化活性没有明显的下降.此外,初步探讨了其催化过程机理.The pyrrolidinecarboxylic functionalized ionic liquid,1-butyl-3-methylimidazolium-（S）-2-pyrrolidinecarboxylic acid salt（[bmim][Pro]）,was prepared using an improved procedure.α,β-Unsaturated carbonyl compounds were selectively synthesized and high yields（88%-97%） were obtained at room temperature in aqueous media when [bmim][Pro] was used as the catalyst for the Knoevenagel reaction between a methylene compound and an aldehyde or ketone.[bmim][Pro] was reused six times without loss of catalytic activity.The catalytic mechanism is briefly discussed.

关 键 词：脯氨酸 离子液体 催化 KNOEVENAGEL缩合 

分 类 号：O643.32[理学—物理化学]