多相双金属Pt-Sn/γ-Al_2O_3催化的胺N-烷基化反应合成仲胺和叔胺  

Heterogeneous Bimetallic Pt-Sn/γ-Al_2O_3 Catalyzed N-Alkylation of Amines:Efficient Synthesis of Secondary and Tertiary Amines

作　　者：赫巍[1] 何松波[1] 孙承林[1] 吴凯凯[1] 王连弟[1] 余正坤[1] 

机构地区：[1]中国科学院大连化学物理研究所,辽宁大连116023

出　　处：《催化学报》2012年第4期717-722,共6页

基　　金：中国科学院领域前沿创新基金(DICPK2009D04);国家重点基础研究发展计划(973计划;2009CB825300)~~

摘　　要：基于借氢策略、醇为烷基化试剂的胺的N-烷基化反应是合成胺类化合物的绿色途径.在无外加氢源条件下,多相双金属Pt-Sn/γ-Al2O3催化剂可高效催化醇为烷基化试剂的伯(仲)胺的N-烷基化反应合成仲(叔)胺,反应副产物为水与极少量亚胺.催化体系的底物适应性好,目标产物收率高;催化剂可以循环使用,具有潜在的工业化应用前景.N-Alkylation of amines with alcohols through a borrowing hydrogen strategy is a green route to amines.Heterogeneous bimetallic Pt-Sn/γ-Al2O3 catalyzed the reactions of primary（secondary） amines with alcohols in the absence of external hydrogen source,efficiently affording secondary（tertiary） amines with water and a small amount of imines as the by-products.Various functional groups in the substrates were tolerated in the catalytic system.The Pt-Sn/γ-Al2O3 catalyst was easily recycled,suggesting its potential application in the production of secondary and tertiary amines.

关 键 词：铂 锡 氧化铝 负载型催化剂 借氢策略 多相催化 N-烷基化 胺 醇 

分 类 号：TQ203.2[化学工程—有机化工]