儿童重症结核病相关危险因素分析  

Analysis of Risk Factors of Severe Tuberculosis in Children

作　　者：刘晓灵[1] 吴喜蓉[2] 焦安夏[2] 尹青琴[2] 孙琳[2] 肖婧[2] 刘芳[2] 苗青[2] 申丹[2] 焦伟伟[2] 申晨[2] 冯卫星[2] 申阿东[2] 

机构地区：[1]首都医科大学附属北京儿童医院,北京100045 [2]首都医科大学附属北京儿童医院儿科研究所,北京100045

出　　处：《标记免疫分析与临床》2012年第2期65-68,共4页Labeled Immunoassays and Clinical Medicine

基　　金：北京市儿科研究所双十计划项目(No.Z111107055311042)

摘　　要：目的调查分析与儿童重症结核病相关的危险因素。方法回顾性研究2002年1月至2010年12月北京儿童医院住院病人中诊断为结核病的0～17岁儿童结核病病例,并对可能影响儿童患重症结核病的危险因素进行单因素及多因素的logistic回归分析。结果年龄、卡介苗接种、结核病接触史及PPD试验4项研究因素P值小于0.05,OR值及95%可信区间分别为:0.716(0.650～0.789),0.606(0.468～0.784),1.483(1.131～1.945)和0.417(0.317～0.549)。结论小于1岁、未接种卡介苗、有结核病密切接触史及PPD试验结果阴性是儿童重症结核病的独立危险因素。Objective To analysis risk factors of severe tuberculosis（TB） in children.Method The retrospective study of children under 17 year of age admitted to Beijing Children＇s Hospital for TB from January 2002 to December 2010 was conducted.The univariate and multivariate logistic regression analysis were used to analyze the relation between risk factors and severe tuberculosis in children.Results The P value of four factors association with severe tuberculosis including age,BCG vaccination,history of exposure to active tuberculosis patient and PPD tuberculin test were less than 0.05,the OR value and 95% CI were 0.716（0.650-0.789）,0.606（0.468-0.784）,1.483（1.131-1.945） and 0.417（0.317-0.549） respectively.Conclusion The results indicate that the age less than 1 year old,non-BCG vaccinated,close contact with active tuberculosis patient and PPD tuberculin skin test negative are independent risk factors with severe tuberculosis in children.

关 键 词：结核病 儿童 LOGISTIC回归 重症 

分 类 号：R725.1[医药卫生—儿科]