TLR4,NF-κB与早期自然流产  

TLR4,NF-κB and Early Spontaneous Abortion

作　　者：李莎[1] 赵先兰[1] 

机构地区：[1]郑州大学第一附属医院妇产科,450052

出　　处：《国际妇产科学杂志》2012年第2期175-178,共4页Journal of International Obstetrics and Gynecology

摘　　要：早期自然流产是产科常见的病理性妊娠之一,病因复杂,发病机制仍不明确。生殖免疫学认为,自然流产是母胎之间免疫平衡失调,母体对胎儿组织产生免疫排斥反应的结果。Toll样受体4(TLR4)是天然免疫系统中一类重要的模式识别受体,TLR4信号转导通路激活核因子-κB(NF-κB),使母胎界面绒毛组织发生某些病理改变,打破原有的免疫平衡,引起流产。因此,TLR4-NF-κB通路可能在早期自然流产发生发展中起重要作用。综述TLR4-NF-κB通路与早期自然流产的关系。Early spontaneous abortion is one of the common pathologic pregnancy in obstetrics.The etiology is complicated, and pathogenesis is not yet clear. Reproductive immunology thinks spontaneous abortion is immune imbalance in maternal- fetal interface, maternal tissues engender immune rejection to fetal tissues.TLR4 is an important kind of pattern recognition receptors in the innate immune system, the activation of TLR4 signal transduction pathway makes some pathological changes in maternal-fetal interface, breaking original immune balance, causing miscarriage. Thus,TLR4-NF-kB pathway may play an important role in the development of early spontaneous abortion. The relationship between TLR4-NF-kB path- way and early spontaneous abortion is reviewed in this paper.

关 键 词：流产 自然 TOLL样受体4 NF-ΚB 妊娠 

分 类 号：R714.21[医药卫生—妇产科学]