632株肠球菌属的临床分布及耐药分析  

Distribution and Drug Resistance of 632 Isolates of Enterococcus

作　　者：谢小芳[1] 周惠琴[1] 沈海英[1] 杨欢[1] 朱雪明[1] 

机构地区：[1]江苏省苏州大学附属第二医院检验科,215004

出　　处：《临床输血与检验》2012年第2期116-118,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的了解肠球菌属的临床分布及对常用抗菌药物的耐药性,指导临床合理选择抗菌药物。方法采用Phoneix100细菌鉴定仪进行菌株鉴定,药敏试验采用Kirby-Bauer法。结果共分离出632株肠球菌属,其中粪肠球菌403株(63.7%),屎肠球菌166株(26.3%),鸟肠球菌49株(7.8%),坚忍肠球菌14株(2.2%);肠球菌属主要分离自呼吸道分泌物229株(36.2%)、中段尿134株(21.3%);肠球菌属对红霉素耐药率最高,其次是利福平、左旋氧氟沙星、环丙沙星,其中屎肠球菌耐药率明显高于其他肠球菌。在粪肠球菌中分别检出耐万古霉素菌株5株(1.3%)和耐利奈唑胺菌株2株(0.5%),而在其他肠球菌中尚未检出。结论肠球菌属在临床标本中的分离情况及耐药性明显不同,临床治疗时应根据菌株类别和药敏结果合理用药;另外,耐万古霉素和利奈唑胺肠球菌的出现应引起临床重视。Objective To analyze the distribution and drug resistance of enterococcus to the common antibiotics,to guide rational application of antibiotics for clinic.Methods The bacteria were identified by Phoneix 100 system,the antimicrobial susceptibility was evaluated by disk diffusion test.Results 632 strains were isolated from clinical specimens,including 403 strains of Enterococcus faecalis（63.7%）,166 strains of Enterococcus faecium（26.3%）,49 strains of Enterococcus avium（7.8%）,14 strains of Enterococcus durans（2.2%）.The strains were mainly isolated from sputa（36.2%） and urine（21.3%）.Enterococcus exhibited the highest resistance to erythromycin.The next resistant drugs were rifampin,levofloxacin,ciprofloxacin successively.As a whole, the resistant rate of Enterococcus faecium was higher than Enterococcus faecalis.During this study,5 strains of vancomycin resistant and 2 strains of linezolid resistant were detected in Enterococcus faecalis,while not founded in other enterococcus.Conclusion In view of the obvious difference in the distribution and drug resistance of enterococcus,the clinical treatment should be rational according to susceptibility test results.Moreover,with the existing of vancomycin and linezolid resistant enterococcus,our clinician should pay more attention.

关 键 词：肠球菌属 临床分布 耐药性 

分 类 号：R378[医药卫生—病原生物学] R969.3[医药卫生—基础医学]