防止复方间苯二酚洗剂变色的方法研究  

Method to prevent discoloration of compound resorcinol lotion

作　　者：袁惠英[1] 唐毅敏[1] 杨佶[1] 

机构地区：[1]南京医科大学附属无锡人民医院,无锡214023

出　　处：《国际药学研究杂志》2012年第2期167-169,共3页Journal of International Pharmaceutical Research

摘　　要：目的分析复方间苯二酚洗剂变色的原因并找出解决办法。方法根据复方间苯二酚洗剂处方的性质,参照抗氧剂和金属络合剂的常用浓度,在复方间苯二酚洗剂中分别加入0.2%焦亚硫酸钠、0.2%亚硫酸氢钠、0.2%焦亚硫酸钠+0.2%亚硫酸氢钠、0.2%焦亚硫酸钠+0.15%硫代硫酸钠、0.2%焦亚硫酸钠+0.02%乙二胺四乙酸二钠、0.2%焦亚硫酸钠+0.1%维生素C,分组放置180 d,于不同光照条件下,观察其颜色变化和含量情况。结果加0.2%焦亚硫酸钠+0.2%亚硫酸氢钠组放置90 d、120 d、180 d后,其颜色和含量测定均符合规定,且显著优于其他各组(P<0.01)。结论选用0.2%焦亚硫酸钠+0.2%亚硫酸氢钠为复方间苯二酚洗剂的抗氧剂,能有效解决该洗剂的变色问题。Objective To analyze the reasons for discoloration of compound resorcinol lotion,and find a solution to the problem.Methods According to the nature of prescription of compound resorcinol lotion and the commonly used concentration of antioxidant and metal complexing agent,0.2% sodium pyrosulfite,0.2% sodium bisulfite,0.2% sodium pyrosulfite plus 0.2% sodium bisulfite,0.2% sodium pyrosulfite plus 0.15% sodium thiosulfate,0.2% sodium pyrosulfite plus 0.02% disodium ethylene diamine tetraacetate,and 0.2% sodium pyrosulfite plus 0.1% vitamin C were added into compound resorcinol lotion respectively.The discoloration of samples was observed and their content determination was conducted in 180 d under different light conditions.Results The color and the content determination of group added with 0.2% sodium pyrosulfite plus 0.2% sodium bisulfite were in line with the standard of description and content determination,and were significantly better than those of other groups（P0.01） after 90,120 and 180 d.Conclusion 0.2% Sodium pyrosulfite plus 0.2% sodium bisulfite could be selected as antioxidants for compound resorcinol lotion to effectively solve the problem of lotion discoloration.

关 键 词：复方间苯二酚洗剂 变色 抗氧剂 

分 类 号：TQ463.2[化学工程—制药化工]