青春期多囊卵巢综合征的ApoB/ApoA1比值对代谢综合征的预测价值  

Apolipoprotein B/apolipoprotein A1 Ratio Is a Good Predictive Marker for Metabolic Syndrome and Pre-MS in Chinese Adolescents with Polycystic Ovary Syndrome

作　　者：尹倩倩[1] 陈晓莉[1] 周冉[1] 黄佳[1] 杨冬梓[1] 

机构地区：[1]中山大学附属孙逸仙纪念医院妇产科生殖中心,广东广州510120

出　　处：《中山大学学报（医学科学版）》2012年第2期206-211,共6页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(81070466);广东省科技计划项目(2010B031600058)

摘　　要：【目的】探讨载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)比值对青春期多囊卵巢综合征(PCOS)患者代谢综合征(MS)和MS前期(pre-MS)状态的预测价值。【方法】对125例青春期PCOS患者进行体格测量和各种血生化参数的测定,PCOS诊断依据2003年鹿特丹标准,MS诊断依据IDF标准,pre-MS定义为≥2项MS组分异常但未达到MS诊断标准的状态。【结果】MS较非MS患者有较高的ApoB/ApoA1比值和较低的ApoA1(P<0.05)。ApoB/ApoA1比值与体质量指数(BMI)、腰围(WC)及甘油三脂(TG)正相关,与高密度脂蛋白胆固醇(HDL-c)负相关(P<0.05);且随MS组分异常数目的增多而升高。肥胖高雄组比非肥胖非高雄组患者的ApoB/ApoA1比值高(P<0.05)。以0.63和0.60为界,ApoB/ApoA1比值预测MS和pre-MS的敏感性和特异度分别为(0.875、0.829)和(0.875、0.881)。【结论】ApoB/ApoA1比值在同时具有高雄和肥胖的青春期PCOS患者中明显升高,对MS及MS前期状态均具有较好的预测价值。【Objective】 We sought to assess if the apolipoprotein B/apolipoprotein A1（ApoB/ApoA1） ratio can be used as a predictive marker for metabolic syndrome（MS） and pre-MS in Chinese adolescents with polycystic ovary syndrome（PCOS）.【Methods】 Anthropometric measurements and biochemical parameters were evaluated in 125 PCOS adolescents diagnosed by the Rotterdam criteria.Based on International Diabetes Federation criteria for MS,patients who have no less than two components of MS but do not meet the criteria for the diagnosis of MS were considered as pre-MS.【Results】 The ApoB/ApoA1 ratios were higher and the levels of ApoA1 were lower in the patients with MS compared with the patients without MS.There was a statistically significant positive correlation between the ApoB/ApoA1 ratio and body mass index（BMI）,waist circumference（WC） and triglycerides（TG） and a significant negative correlation of the ApoB/ApoA1 ratio with high-density lipoprotein cholesterol（HDL-c）（P 0.05）.The ApoB/ApoA1 ratio increased significantly as the number of MS components increased,and provided 87.5% of sensitivity and 82.9% of specificity with a threshold value of 0.63 for MS and 87.5% of sensitivity and 88.1% of specificity with a threshold value of 0.60 for pre-MS.【Conclusion】 The ApoB/ApoA1 ratio was significantly higher in obese adolescent PCOS patients with high levels of free androgen index（FAI） and was a good predictive marker for MS and pre-MS in Chinese adolescents with PCOS.

关 键 词：载脂蛋白B/载脂蛋白A1 代谢综合征 青春期 多囊卵巢综合征 

分 类 号：R589[医药卫生—内分泌]