系膜增生性肾小球肾炎红细胞和白细胞免疫粘附功能及其相关性的研究  

Correlative study of erythrocyte and leukocyte immune - adhering function in 31 children with mesangio - proliferative glqmerulonephritis

作　　者：顾岚[1] 苏渊[1] 吴莉[1] 何威逊[2] 罗运九[2] 朱光华[2] 任志德[2] 

机构地区：[1]第二军医大学长征医院儿科,200003 [2]上海市儿童医院,200040

出　　处：《临床儿科杂志》2000年第1期3-5,共3页Journal of Clinical Pediatrics

摘　　要：为从红细胞免疫角度探讨系膜增生性肾小球肾炎(MsPGN)患儿的免疫发病机制,用郭峰法检测了31例MsPGN的红细胞和白细胞免疫粘附功能,并进行比较研究。结果提示:(1)作为检测红细胞免疫粘附功能的红细胞C3b受体花环率(RCR)和肿瘤红细胞花环率(TRR)均较对照组明显降低,红细胞免疫复合物花环率(RICR)差异不显著。(2)作为检测白细胞免疫粘附功能的肿瘤粒细胞花环率(TNR)和肿瘤淋巴细胞花环率(TLR)均较对照组降低,(3)红细胞和白细胞免疫粘附功能的下降程度呈显著正相关。结论:红细胞和白细胞免疫粘附功能紊乱可能是MsPGN的发病机理之一。提高红细胞和白细胞免疫粘附功能,可能为临床治疗MsPGN提供新思路。RCR、RICR、TRR、TNR、TLR均可作为判断病情、疗效、预后的指标而应用于临床。To explore the immune pathogenesis in the children with mesangioproliferative glomerulonephritis (Ms PGN), immune -adhering function of erythrocytes and leukocytes were measured in 31 MsPGN patients and 30 normal control children by rosette tests including RCR, RICR, TRR, TNR and TLR. The results showed that RCR and TRR as immune - adhering function of erythrocytes, TNR and TLR as immune - adhering function of leukocytes in the MsPGN patients all decreased significantly comparing to control cases (P<0. 05),while no significant difference of RICR were observed between two groups (P>0. 05). The decreased immune -adhering function of erythrocytes were positively correlated with decreased immune - adhering function of leukocytes. It is concluded that the decreased immune - adhering function of erythrocytes and leukocytes probably play an important role in the pathogenesis of MsPGN. The rosette tests including RCR, RICR, TRR, TNR and TLR may be useful marker for judging clinical situation, therapeutical effect and prognosis.

关 键 词：系膜增生性 肾小球肾炎 红细胞 白细胞 儿童 

分 类 号：R726.91[医药卫生—儿科]