1000名健康小儿血清骨钙素含量的测定及其分析  

Analysis and Measurement of Serum BGP Quantity in 1000 normal children

作　　者：王斌[1] 张萌萌 朱丽娟 吴乃宝 刘淑芹 姜传 

机构地区：[1]中国第一汽车集团公司职工医院,吉林长春130011 [2]长春市二院,130062

出　　处：《中国实验诊断学》2000年第1期12-13,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的通过对不同年龄段健康儿童血清骨钙素（ＢＧＰ）含量的测定，评价正常儿童的骨骼生长发育时血清ＢＧＰ的含量，为代谢性骨病的诊断、治疗提供理论依据。方法用放射免疫的方法检测１０００名１１４岁的健康儿童血中ＢＧＰ的含量。结果 １１４岁小儿血清ＢＧＰ的含量在１０．６００－２４．８６６ｎｇ／ｍｌ之间，随着年龄增长，含量增加，青春期达高峰，１３组女孩血清ＢＧＰ含量明显高于男孩（Ｐ＜０．０１）。４７岁组男、女血清ＢＧＰ含量无差别，７１２岁组，女孩血清ＢＧＰ含量明显高于男孩（Ｐ＜０．０５）。女孩血清ＢＧＰ在８岁后明显升高，１３岁以后呈平台期。男孩血清ＢＧＰ在１２岁以后迅速增加。结论儿童血清ＢＧＰ含量（与年龄及身高的增长呈正相关。）在不同的生长发育时期，与性别有关。ＢＧＰ的测定可以评价正常儿童的骨骼生长发育状况，在代谢性骨病的诊治中具有重要意义。Objective To evaluate the normal levels of serum BCP and growing state of bone in normal children by the measurement of serum BGP in normal children of different ages and to offer the theoretical basis in the diagnosis and treatment of metabolic hone diseases. Metals The serum BGP was measure in l000 healthy children by RIA, including 500 boys and 500 girls, ranging in age from one to fourteen years old. Results Quantity of BGP was between 10.600-24. 866ng/ml in healthy children from one to fourteen years old. The older the ages, the higher the BGP levels. The levels of BGP in girls from one to three years old and from seven to twelve years old were significantly higher than those in the boys (p<0.01) in the same age group. But the levels of BGP in boys from 12 to 14 were signifcantly higher than these in the girls in the same age groups (P<0.05). The levels of BGP repidly rose after & years old in the girls and after 12 years old in boys. Conclusion The levels of serum BGP in normal children were associated with the age growing, and body height, and they were associated with sex at different growing stage. The levels of BGP indicated that they had important significance at clinic in evaluation of bone growing of normal children and in diagnosis and treatment of metaolic bone diseases.

关 键 词：儿童 血清 骨钙素 放射免疫分析 

分 类 号：R179[医药卫生—妇幼卫生保健]