左旋卡尼汀与促红素联合应用对透析患者贫血和营养状况的影响  

Effect of L-carnitine and rhEPO on anemia and nutritional state in renal hemodialysis patients

作　　者：毛艳卿 

机构地区：[1]桂林市第二人民医院肾内科,广西桂林541001

出　　处：《现代预防医学》2012年第9期2164-2165,2174,共3页Modern Preventive Medicine

摘　　要：目的观察左旋卡尼汀联用促红素治疗透析患者贫血及对其营养状态改善的临床疗效。方法回顾性分析某院自2008年1月～2010年10月收治的维持血液透析的贫血患者52例,随机分为二组,观察组27例给予左旋卡尼汀联用促红素,对照组25例单独给用促红素,观察二组患者治疗前后血红蛋白(Hb)、血细胞比容(Hct)的变化,治疗后4、8、12周的血清白蛋白(Alb)、前白蛋白(PA)、血清转铁蛋白(TF)、相对体重(KBW)。结果左旋卡尼汀联用促红素组及促红素组针对Hb、Hct值与治疗前比较,差异均有统计学意义,P﹤0.05,P﹤0.01。治疗后左旋卡尼汀联用促红素组Hb、Hct与促红组比较,差异均有统计学意义,P﹤0.05。观察组与对照组治疗8周及12周,与治疗前比较,Alb、PA、TF、KBW均有显著升高,P﹤0.05,P﹤0.01。观察组升高水平高于对照组,P﹤0.05。结论左旋卡尼汀与促红素联用可改善透析患者贫血状态,提高营养水平。OBJECTIVE To evaluate the effect of L-carnitine plus rhEPO on anemia and nutritional state of nephritic hemodialysis patients.METHODS We retrospectively analyzed 52 cases who were treated for hemodialysis from January 2008 to October 2010.The 52 cases were randomly divided into 2 groups of 27 cases in the control group who were given L-carnitine plus rhEPO,and 25 case in experimental group who were given rhEPO.Contrasted the levels of hemoglobin（Hb）,hematocrit（Hct）,and after 4 weeks,8 weeks,12 weeks treatment,serum albumin（A lb）,prealbumin（PA）,serum transferrin（TF）,relative body weight（KBW）were compared.RESULTS There were significant differences in the levels of Hb,Hct,P﹤0.05,P﹤0.01.The level of A lb,PA,TF,KBW after 8 weeks,12 weeks treatment,P﹤0.05,P﹤0.01.CONCLUSION L-carnitine plus rhEPO treatment to patients with hemodialysis can improve the levels of anemia and nutritional state.

关 键 词：左旋卡尼汀 促红素 透析 贫血 营养状况 

分 类 号：R969.4[医药卫生—药理学]