家族性桥本病及其并发病的临床调查研究  

Clinical investigation and research of familial Hashimoto disease and its concomitant disease.

作　　者：黄继胜[1] 朱玉柱[1] 高鹏[1] 刘爱琴 

机构地区：[1]河南省商丘市第一人民医院外科,476100

出　　处：《中国实用外科杂志》2000年第2期97-99,共3页Chinese Journal of Practical Surgery

摘　　要：目的　探讨家族性桥本病的遗传方式及其伴发病的发生情况。方法　采用手术、穿刺病检、放射免疫、系谱分析等方法 ,追踪调查 3个家系 6 7人。结果　确诊病人 2 1例 ,其中女 2 0例 ,男 1例 ,男女发病率有极显著性差异 (P <0 0 1)。系谱分析中可见几代连续传递 ;病人的双亲中均有一方是病人 ,双亲无病者子女未见患病。伴发病 :本组腺内、外伴发病 9例 (4 3 % ) ,其中甲状腺癌 2例 (9 5 % ) ,甲状腺机能亢进 1例 (4 8% ) ,甲状腺机能减退 3例 (14 3 % ) ,Grave突眼伴顽固性高血压 1例 (4 8% ) ,Grave突眼伴屈光不正 1例 (4 8% ) ,甲状腺腺瘤 1例 (4 8% )。结论　家族性桥本病的遗传方式符合Mendel定律的单基因遗传 ,即常染色体显性遗传的一种特殊形式—从性遗传。其伴发病的发生率高于散发性桥本病 。Objective To explore the hereditary way of familial Hashimoto disease and the conditions of its concomitant disease.Methods 67 persons of 3 Hashimoto disease families were investigated by the use of operation,pathological analysis of puncture,radioimmune assay(RIA)and pedigree analysis.Results 21 cases of Hashimoto disease were determined(20 female and 1 male).The incidence showed great difference between female and male(P<0\^01).In pedigree continuous transmission in a few generation was found.One of the parents of the patients must occur this disease.But,the children whose parents had good health had not this disease.The concomitant diseases:thyroid cancer 2 (9\^5%),hyperthyroidism 1(4\^8%),hypothyroidism 3(14\^3%),Grave protruding bug-eyed with hypertension 1(4\^8%),Grave protruding bug-eyed with ametropia 1(4\^8%),thyroid adenoma 1 (4\^8%).There were 9 concomitant diseases(43%)inside and outside of the gland .Conclusion The hereditary way of Hashimoto disease in family tree accord with Mendel law of simple genotypically heredity.The incidence of the concomitant diseases was higher than that in sporadic Hashimoto disease.

关 键 词：桥本病 家庭性 遗传 并发症 

分 类 号：R581.4[医药卫生—内分泌]