绝经后骨质疏松症患者性激素、细胞因子及骨代谢指标的变化及关系  

The changes and relationship with sex hormone,cytokine and bone metabolic index in postmenopausal osteoporosis patients

作　　者：易伟莲[1] 廖德权[1] 林柏云[1] 肖亚景[1] 袁汉尧[1] 

机构地区：[1]广东医学院附属医院,广东湛江524001

出　　处：《检验医学》2012年第4期296-298,共3页Laboratory Medicine

基　　金：广东省湛江市科技攻关项目(2010C3103013)

摘　　要：目的探讨绝经后骨质疏松症(POP)患者性激素、细胞因子及骨代谢指标的相关性。方法根据腰椎骨密度(BMD)扫描结果将受试者分为3组,即POP组48例、绝经后非骨质疏松(NOP)组32例及绝经前健康对照组30名;采用放射免疫法、化学发光法及酶联免疫吸附试验(ELISA)测定110例受试者血清雌二醇(E2)、白细胞介素-6(IL-6)、胰岛素样生长因子-1(IGF-1)、骨碱性磷酸酶(BAP)及氨基端中段骨钙素(N-BGP)的水平,并进行相关性分析。结果 POP组患者血清IL-6、N-BGP及BAP水平增高,高于NOP组及正常对照组(P<0.01),而BMD和E2、IGF-1的水平则低于NOP组及正常对照组(P<0.01);IGF-1与BMD、E2呈显著正相关(r=0.572、0.436,P<0.01),与年龄呈显著负相关(r=-0.541,P<0.01);IL-6与BMD、E2呈负相关(r=-0.584、-0.435,P<0.05),与N-BGP、BAP呈正相关(r=0.546、0.354,P<0.05);BMD与IL-6、年龄、N-BGP、BAP呈负相关(P<0.05),与E2、IGF-1呈正相关(P<0.05)。结论 POP患者IL-6、N-BGP、BAP、E2及IGF-1水平可作为临床诊治POP的辅助指标。Objective To investigate the correlation of sex hormone,cytokine and bone metabolic index in postmenopausal osteoporosis（POP） patients.Methods According to the results of the lumbar spine bone mineral density（BMD）,the subjects were classified into 3 groups： POP group（48 cases）,non-osteoporotic postmenopausal（NOP） group（32 cases） and premenopausal healthy group（30 cases）.By radioimmunoassay,chemiluminescence and enzyme-linked immunosorbent assay（ELISA）,sera of all 110 cases were tested for the levels of estradiol（E2）,interleukin-6（IL-6）,insulin-like growth factor-1（IGF-1）,bone alkaline phosphatase（BAP） and osteocalcin middle amino terminal（N-BGP）,and the correlation was analyzed.Results The levels of IL-6,N-BGP and BAP of POP group were increased and higher than those of NOP group and control group（P0.01）,while the BMD and the levels of E2 and IGF-1 of POP group were lower than those of NOP group and control group（P0.01）.IGF-1 with BMD and E2 showed a significant positive correlation（r=0.572 and 0.436,P0.01）,and IGF-1 was negatively correlated significantly with age（r=-0.541,P0.01）.IL-6 with BMD and E2 was negatively correlated（r=-0.584 and-0.435,P0.05）,and IL-6 with N-BGP and BAP was positively correlated（r=0.546 and 0.354,P0.05）.BMD with IL-6,age,N-BGP and BAP was negatively correlated（P0.05）,and BMD with E2 and IGF-1 was positively correlated（P0.05）.Conclusions The levels of IL-6,N-BGP,BAP,E2 and IGF-1 may be indices of clinical diagnosis and treatment of POP.

关 键 词：性激素 细胞因子 骨代谢指标 骨质疏松 绝经 

分 类 号：R446.62[医药卫生—诊断学]