门冬氨酸钾注射液联合氯化钾缓释片治疗重度低钾血症的临床观察  

Study on the effect of potassium L-aspartate injection combined with potassium chloride sustained-release tablets on severe hypokalemia

作　　者：曲文秀[1] 陈列[1] 谭昊[1] 焦光宇[1] 

机构地区：[1]中国医科大学附属盛京医院第一呼吸科,沈阳110004

出　　处：《实用药物与临床》2012年第4期202-203,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的评价门冬氨酸钾注射液联合氯化钾缓释片治疗重度低钾血症的临床疗效。方法入选患者为我院2011年6-10月收治的重度低钾血症患者60例。所有患者均口服氯化钾缓释片2.0 g,4次/d,实验组(30例)给予门冬氨酸钾注射液20 mL加入生理盐水500 mL中静脉滴注,对照组(30例)给予氯化钾注射液15 mL加入生理盐水500 mL中静脉滴注,实验组补钾量为6.73 g/d,对照组补钾量为6.825 g/d,两组均每日1次,共3 d。结果治疗后实验组和对照组的临床显效率分别为86.67%和83.33%,两组比较差异无统计学意义(P=0.151)。实验组血钾值从治疗前的(2.07±0.25)mmol/L升高到治疗结束时的(3.85±0.46)mmol/L,血钾平均升高(1.78±0.35)mmol/L;对照组血钾值从治疗前的(2.07±0.26)mmol/L升高到治疗结束时的(3.8±0.43)mmol/L,血钾平均升高(1.72±0.31)mmol/L,组间比较差异无统计学意义(P=0.574)。结论实验组与对照组治疗重度低钾血症疗效相当,可以有效地治疗各种原因引起的重度低钾血症。Objective To estimate the clinical effects of potassium L-aspartate injection combined with potassium chloride sustained-release tablets on severe hypokalemia.Methods 60 severe hypokalemia patients in our hospital from June to October 2011 were selected.The patients were taken potassium chloride sustained-release tablets 2.0 g four times a day.Test group（30 patients） was intravenously dripped by potassium L-aspartate injection（20 mL） added in 5% Glucose（or saline） 500 mL,control group（30 patients） was given chloratum kalium injection（15 mL） added in 5% Glucose（or saline） 500 mL,the supplement amount of Kalium were 6.73 g/d in test group and 6.825 g/d in control group,once daily,time of therapy was 3 d.Results The efficacy rates of test group and control group were 86.67% and 83.33% respectively（P= 0.151）.The Kalium dose of test group increased,and the increased average of test group and control group were（1.78±0.35）mmol/L and（1.72±0.31）mmol/L（P=0.574）.Conclusion The clinical efficacy is correspond between the two groups,and the severe hypokalemia caused from various kinds of reasons can be treated by Potassium L-asparate and potassium chloride sustained tablets effectively.

关 键 词：门冬氨酸钾 重度低钾血症 

分 类 号：R591.1[医药卫生—内科学]