颅脑术后颅内感染42例病原学分析与治疗体会  

Analysis of etiology and experiences of treatments for 42 patients with intracranial infection after craniocerebral operations

作　　者：刘海巍[1] 陶胜忠[1] 牛光明[1] 周兴[1] 牛国策[1] 孙所辉[1] 

机构地区：[1]郑州大学第二附属医院神经外科,郑州450014

出　　处：《中国实用神经疾病杂志》2012年第6期18-20,共3页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨颅脑术后颅内感染的病因和治疗策略。方法对2007-09-2011-07我科收治的42例颅脑术后颅内感染患者脑脊液和(或)脑脓肿液中分离出的致病菌及其药物敏感性和治疗进行分析。结果引起颅内感染的致病菌中革兰阳性菌占64.36%(65株),革兰阴性菌占33.66%(34株),真菌占1.98%(2株)。对革兰阳性菌敏感的抗生素有头孢噻肟钠、万古霉素和利奈唑胺等;对革兰阴性菌敏感的抗生素有美罗培南、头孢哌酮舒巴坦钠等;对白色念珠菌敏感的抗生素有氟康唑等。结论颅脑术后颅内感染仍以革兰阳性菌为主,治疗应以静脉和鞘内联合应用抗生素为主。Objective To discuss the etiology and treatment strategies of intracranial infection after craniocerebral operations.Methods The pathogenic bacteria and these drug susceptibility which were isolated from cerebrospinal fluid（CSF） and pus of 42 patients with intracranial infection after craniocerebral operations treated in our department from September 2007 to July 2011 were analyzed.Results The G＋ bacteria accounted for 65.36%,the G-bacteria accounted for 32.66% and the fungus accounted for 1.98% in the pathogenic bacteria caused intracranial infection.Cefotaxime Sodium,Vancomycin,Linezolid and so on were sensitive to G＋bacteria.Meropenem,Cefoperazone Sodium and Sulbactam Sodium and so on were sensitive to G-bacteria.Luconazole and so on were sensitive to Monilia albican.Conclusion The G＋ bacteria take the majority of the pathogenic bacteria caused intracranial infection and the treatment should take the application of sensitive antibiotics by intravenous injection combined with intrathecal injection.

关 键 词：颅内感染 致病菌 药物敏感性 敏感抗生素 鞘内注射 

分 类 号：R372[医药卫生—病原生物学] R619.3[医药卫生—基础医学]