难治性肺炎支原体肺炎急性期治疗对肺炎后呼吸道事件的影响  

Effect of Acute Phase Treatment of Refractory Mycoplasma Pneumoniae Pneumonia on the Respiratory Events after Pneumonia

作　　者：滕源[1] 黄先玫[1] 沈剑[1] 梁冰[1] 毕爱红[2] 

机构地区：[1]杭州市第一人民医院儿科,310006 [2]浙江省人民医院

出　　处：《医学研究杂志》2012年第4期143-145,共3页Journal of Medical Research

摘　　要：目的探讨儿童难治性肺炎支原体肺炎(RMPP)急性期的治疗方式是否影响肺炎后慢性咳嗽、反复呼吸道感染的发生。方法对63例3～14岁RMPP患儿进行回顾性分析,治疗方式分为是否静脉用红霉素、是否全身用肾上腺皮质激素(激素)、是否纤维支气管镜(简称纤支镜)镜下冲洗、是否静脉用丙种球蛋白(丙球),肺炎后(指病程6周后)呼吸道事件分为慢性咳嗽、反复呼吸道感染,进行多因素Logistic回归分析。结果多因素Logistic回归分析显示,RMPP急性期全身用激素与肺炎后慢性咳嗽(回归系数=-1.869,P=0.003)、反复呼吸道感染(回归系数=-1.359,P=0.040)的发生呈负相关,急性期进行纤支镜镜下冲洗与肺炎后慢性咳嗽(回归系数=-1.734,P=0.016)的发生负相关,结果有统计学显著意义。结论儿童RMPP急性期全身用激素、进行纤支镜镜下冲洗可以减少肺炎后慢性咳嗽的发生,全身用激素可以减少肺炎后反复呼吸道感染的发生。Objective To investigate whether the treatment in acute phase of refractory mycoplasma pneumoniae pneumonia （RM- PP） in children affected chronic cough, recurrent respiratory tract infection after pneumonia. Methods Clinical data of 63 children（ aged 3 - 14 years old） with RMPP who were admitted in our center from March 2007 to March 2010 were retrospectively analyzed. The treatment method was selectedbased on whether intravenous treatment with erythromycin, whether systemic adrenocorticotropic hormone （hormone） ,whether the bronchoscope （bronchoscopy） endoscopic flushing, whether intravenous immunoglobulin （gammaglobulin）. Respiratory events after pneumonia （mean duration after 6 weeks） were divided into chronic cough, recurrent respiratory tract infections. Logistic regression analysis of multiple factors was performed using SPSS versionlS. 0. Results Multivariate Logistic regression analysis showed that systemic hormones in acute phase of RMPP had negative correlation with chronic cough （regression coefficient = - 1. 869 ,P = 0. 003 ） , recurrent respiratory tract infection （ regression coefficient = - 1. 359,P = 0. 040） after pneumonia. Fiberoptic endoscopic flushing in acute phase of RMPP had negative correlation with the chronic cough after pneumonia （regression coefficient = - 1. 734, P = 0. 016） . The result was statistically significant. Conclusion In acute phase of Children RMPP,systemic hormone,the fiberoptic endoscope washing can reduce the incidence of chronic cough after pneumonia. Systemic hormones can reduce recurrent respiratory tract infection after pneumonia.

关 键 词：支原体肺炎 慢性咳嗽 反复呼吸道感染 儿童 

分 类 号：R725.631[医药卫生—儿科]