麻风病神经损伤分子机制的研究进展  

Progress on Molecular Mechanisms of Nerve Damage in Leprosy

作　　者：翁小满[1] 

机构地区：[1]北京友谊医院、北京热带医学研究所,北京100050

出　　处：《中国皮肤性病学杂志》2012年第5期445-448,共4页The Chinese Journal of Dermatovenereology

摘　　要：麻风病的神经病变是导致患者残疾、丧失劳动力而成为公共卫生问题的关键。为早期预测神经损伤,研发防止或干预神经损伤的药物,本文综述麻风杆菌侵犯人外周神经施万细胞后导致的免疫炎性反应、脱髓鞘与轴损伤等病变的分子机理。另一方面,评述可早期预测神经损伤的生物标记物的研究进展。The deformities and disabilities caused by leprosy neuropalhy is a key puhlic health problem in leprosy. Thispaper reviews the molecular mechanisms of nerve damage invoved in the immunological inflammation,de-myelination and axonal injury that caused by M. Leprae invasion of Schwann cells in peripheral nerves. Inaddition il also reviews the advance in the bio-markcrs for the prediction of early nerve damage in leprosy.

关 键 词：麻风病 神经损伤 生物标记物 

分 类 号：R755[医药卫生—皮肤病学与性病学]