胰岛素和亚硒酸钠最佳配比组方研究  

Study on Optimal Combination Ratio of Insulin and Sodium Selenite

作　　者：陈莉娜[1,2] 蔡玉龙[3] 吕娟[1,2] 曾爱国[1] 袁秉祥[1] 王冰 

机构地区：[1]西安交通大学医学院,陕西西安710061 [2]陕西省新型治疗疫苗工程技术研究中心,陕西西安710061 [3]陕西省医疗器械检测中心,陕西西安710075

出　　处：《中国药业》2012年第8期36-37,共2页China Pharmaceuticals

基　　金：国家自然科学青年基金;项目编号:30901808;陕西省科技统筹创新工程计划项目;项目编号:2011KTCL03-20

摘　　要：目的确定普通胰岛素与亚硒酸钠降血糖作用的最佳组方配比。方法采用小剂量链脲佐菌素腹腔注射联合高糖高脂饲养的大鼠模型,以血糖降低百分率为考察指标,根据权重配方法设不同配比组方6组,分析结果得出最佳理论配比,并进一步做确证性试验考察二者的相互关系。结果胰岛素与亚硒酸钠对血糖的控制为协同作用,二者比例为1 U∶5μg时可显著降低血糖。结论胰岛素和亚硒酸钠的最佳配比为1 U∶5μg。Objective To determine the optimal combination ratio of regular insulin and sodium selenite for reducing blood glu- cose. Methods High-fat high-glucose diet-induced rats were injected with a low dose of streptozotocin into peritoneal. Decreasing percentage of blood glucose was used as reference index. 6 formulas with different combination ratios were designed according to the weighted modification method. The results were analyzed for obtaining the optimal theoretical combination ratio. Then the further confir- mation test was conducted for investigating the relation between regular insulin and sodium selenite. Results Regular insulin and sodium selenite had the additive effect on blood glucose. When the ratio was 1 U：5 μg,regular insulin and sodium selenite could reduce blood glucose significantly. Conclusion The optimal combination ratio of regular insulin and sodium selenite is 1 U ： 5μg.

关 键 词：胰岛素 亚硒酸钠 权重配方法 糖尿病大鼠 血糖 

分 类 号：R965[医药卫生—药理学] R977.15[医药卫生—药学]