脂代谢及血清内脂素水平与绝经后骨质疏松症的相关性研究  

Study on the correlations between the levels of lipid metabolism and serum visfatin and postmenopausal osteoporosis

作　　者：陈俊杰[1] 李晴晴[1] 夏瑢[2] 

机构地区：[1]浙江省中医院,浙江杭州310006 [2]浙江中医药大学,浙江杭州310053

出　　处：《中医正骨》2012年第4期16-18,共3页The Journal of Traditional Chinese Orthopedics and Traumatology

基　　金：浙江省中医管理局科研专项课题(20050832)

摘　　要：目的:探讨脂代谢及血清内脂素水平与绝经后骨质疏松症的相关性。方法:依据1994年世界卫生组织骨质疏松症诊断标准,选取2010年3月至2011年5月在浙江省中医院骨科就诊的绝经1年以上的女性骨量减少与骨质疏松症患者各30例作为研究对象;检测患者血清中血脂、内脂素及骨代谢指标的水平,分析对比骨质疏松症患者与骨量减少患者血脂及内脂素水平的差异;并分别对血脂、内脂素水平与骨密度、骨代谢指标间的相关性作直线相关分析。结果:骨质疏松组患者血清中总胆固醇含量和内脂素水平均高于骨量减少组(t=-2.481,P=0.016;t=-2.850,P=0.006);患者血清中总胆固醇和内脂素水平均与骨密度呈负相关(r=-0.524,P=0.000;r=-0.523,P=0.000);与骨吸收指标抗酒石酸酸性磷酸酶呈正相关(r=0.426,P=0.001;r=0.674,P=0.000);与骨形成指标骨型碱性磷酸酶无相关性(r=-0.208,P=0.110;r=-0.240,P=0.065)。结论:脂代谢障碍,血清总胆固醇水平升高及内脂素异常表达可能具有影响骨代谢、加快骨吸收的作用,并由此影响绝经后骨质疏松症的发病,但其具体机制仍需进一步研究。Objective：To explore the correlations between the levels of lipid metabolism and serum visfatin and postmenopausal osteoporosis（PMOP）.Methods：According to the diagnostic criteria of osteoporosis formulated by world health organization in 1994,30 cases with osteopenia and 30 cases with osteoporosis were selected from the female patients with menopausal period more than 1 year and treated in orthopaedic department of Hospital of Chinese medicine of Zhejiang Province from March 2010 to May 2011.The levels of lipid,visfatin and index of bone metabolism in blood serum of patients were measured.The differences in levels of lipid and visfatin were analyzed and compared between osteoporosis patients and osteopenia patients.Linear correlation analysis was made on the relationships among lipid,visfatin level,bone mineral density（BMD） and bone metabolism index respectively.Results：Cholesterol total（CHOL） contents and visfatin levels in blood serum of osteoporosis patients were all higher than those of osteopenia patients（t=-2.481,P=0.016;t=-2.850,P=0.006）.Both serum CHOL level and serum visfatin level were correlated negatively with BMD（r=-0.524,P=0.000;r=-0.523,P=0.000） and were correlated positively with the level of tartrate-resistant acid phosphatase（r=0.426,P=0.001;r=0.674,P=0.000） and had no correlations with the level of bone alkaline phosphatase（r=-0.208,P=0.110;r=-0.240,P=0.065）.Conclusion：As the result of lipid metabolism disorders,elevated levels of serum CHOL and abnormal expression of visfatin may have effects on PMOP attack through affecting bone metabolism and speeding up bone absorption,however,the concrete mechanism shoule be further studied.

关 键 词：骨质疏松 绝经后 脂代谢障碍 烟酰胺磷酸核糖基转移酶 直线相关分析 

分 类 号：R580[医药卫生—内分泌]