20万项次过敏原特异性IgE检测结果  

Two Hundred Thousands Results of Allergen Specific IgE Detection

作　　者：王瑞琦[1] 张宏誉[1] 

机构地区：[1]中国医学科学院 北京协和医学院 北京协和医院变态反应科,北京100730

出　　处：《中华临床免疫和变态反应杂志》2012年第1期18-23,共6页Chinese Journal of Allergy & Clinical Immunology

摘　　要：目的分析临床常见吸入物过敏原和重要食物过敏原的种类。方法依据北京协和医院变态反应科近3年来应用ImmunoCAP过敏原检测系统所做的过敏原特异性IgE(specificIgE,sIgE)检测结果,统计每种过敏原的检测量、阳性检出量和阳性率,并对阳性检出量进行排序分析。结果近3年间,过敏原sIgE检测共计215210项次,其中吸入物过敏原76%、食物过敏原22%、其他过敏原(如药物、昆虫等)2%。常见吸入物过敏原18种,包括户尘螨、粉尘螨、蒿属花粉、葎草花粉、链格孢、白蜡花粉、柏树花粉、豚草花粉、桦树花粉、蟑螂、梧桐花粉、苍耳花粉、屋尘、多主枝孢、狗皮屑、猫皮屑、鹅毛草花粉和烟曲霉等,其阳性检出量之和占单价吸入物过敏原阳性检出量的95%。重要食物过敏原包括鸡蛋、牛奶、花生、大豆、虾、蟹、谷物、坚果和水果等。另外有27种吸入物和42种食物过敏原的阳性检出量很低,甚至有些未见阳性病例。吸入物过筛(Phadiatop)和食物过筛(fx5)是最常用的混合吸入物和混合食物检测项目。结论过敏原种类繁多,但临床常见吸入物和重要食物过敏原的种类却有限,有些极其罕见,我国常见吸入物和重要食物过敏原的种类与国外报道基本一致。Objective To analyze and determine the common inhalant allergens and important food allergens in clinical practice. Methods Base on the allergen-specific IgE （slgE） results detected by ImmunoCAP system in Department of Allergy, Peking Union Medical College Hospital in the past three years, the test amount, the positive results number, and the positive rate of each allergen were calculated respectively, and the sorting analysis of positive results number was performed. Results 215 210 detection were assayed in the past 3 years, 76% of them were inhalant allergens slgE, 22% were food allergens slgE, and 2% were other allergens （including drugs and insects et al） slgE. There were 18 kinds of common inhalant allergens, including Dermatophagoides pteronyssinus, Dermatophagoides farinae, mugwort, Japanese hop, Altermaria alternate, white ash, mountain juniper, common ragweed, common silver birch, Cockroach （ German）, maple leaf sycamore, cocklebur, hand dander, goosefoot （Lambs quarters）, and Aspergillus fumigatus, which contributed to 95% of inhalant allergen slgE positive results. The important food allergens were egg, milk, peanut, soybean, shrimp, crab, grain, nut and fruit. The positive sIgE results number of 27 kinds of inhalant and 42 kinds of food allergens was less then ten in the past 3 years, and no positive result was found in some of them. Phadiatop and fx5 were the most common screening tests used in clinical practice. Conclusions The variety of allergens is great, but the common inhalant and important food allergens are limited in clinical practice. Some allergens are really rare. The common inhalant and important food allergens spectrum of China is in accord with data of foreign publications.

关 键 词：过敏原 特异性免疫球蛋白E 过敏原特异性 

分 类 号：R446.6[医药卫生—诊断学]