莫诺苷对二磷酸腺苷诱导兔血小板聚集后血栓素B_2的影响  

Effects of Morroniside on Inhibiting Thromboxane B_2 after Platelet Aggregation Induced by Adenosine Diphosphate in Rabbits

作　　者：左玮[1,2] 王晓锋[2,3] 艾厚喜[2] 张丽[2] 季晖[1] 陈乃宏[3] 王文[2] 

机构地区：[1]中国药科大学,江苏南京市210009 [2]首都医科大学宣武医院,北京市100053 [3]中国医学科学院药物所,北京市100050

出　　处：《中国康复理论与实践》2012年第4期329-330,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金："重大新药创制"科技重大专项(2009ZX09103-366);国家自然科学基金项目(30973893);北京市自然科学基金项目(7102077);北京市教委(PXM2011_014226_07_000071);2011年北京市卫生系统高层次卫生技术人才

摘　　要：目的观察莫诺苷对二磷酸腺苷(ADP)诱导兔血小板聚集后血栓素(TX)B2含量的影响。方法利用酶联免疫吸附剂测定法(ELISA)试剂盒,检测不同条件下ADP诱导血小板聚集后TXB2的含量。结果与对照组相比,莫诺苷能显著抑制由ADP诱导兔血小板聚集后TXB2的升高(P<0.001)。结论莫诺苷可以不同程度抑制ADP诱导兔血小板聚集后TXB2的生成。Objective To study the effects of morroniside on thromboxane B2 in the condition of platelet aggregation in rabbits induced by adenosine diphosphate（ADP）.Methods The level of TXB2 was determined by enzyme-linked immunosorbent assay（ELISA）.Results Compared with the controls,morroniside significantly inhibited the increase of TXB2 induced by ADP（P0.001）.Conclusion Morroniside can inhibit the level of TXB2 by inhibiting the platelet aggregation in rabbits induced by ADP.

关 键 词：莫诺苷 血小板聚集 血栓素B2 兔 

分 类 号：R285.5[医药卫生—中药学]