莫诺苷对二磷酸腺苷诱导兔血小板聚集后环氧酶的影响  

Effects of Morroniside on Cycloxygenase after Platelet Aggregation Induced by Adenosine Diphosphate in Rabbits

作　　者：孙盼莉[1,2] 魏守蓉[1] 王晓锋[2,3] 王文[2] 陈乃宏[3] 薛存宽[1] 刘浩[1] 

机构地区：[1]华中科技大学同济医学院,湖北武汉市430030 [2]首都医科大学宣武医院,北京市100053 [3]中国医学科学院药物所,北京市100050

出　　处：《中国康复理论与实践》2012年第4期331-332,共2页Chinese Journal of Rehabilitation Theory and Practice

基　　金："重大新药创制"科技重大专项(2009ZX09103-366);国家自然科学基金项目(81173575;30740053);北京市自然科学基金项目(7062031);北京市教委(PXM2011_014226_07_000071);2011年北京市卫生系统高层次卫生技术人才

摘　　要：目的研究莫诺苷对二磷酸腺苷(ADP)诱导兔血小板聚集后环氧酶(Cox)含量的影响。方法利用酶联免疫吸附剂测定法(ELISA)检测不同给药组间ADP诱导体外分离的兔血小板聚集后Cox的含量。结果与空白对照组相比,莫诺苷各剂量组均能显著降低ADP诱导兔血小板聚集后Cox的含量(P<0.001),并具有较好的浓度依赖性,其中高剂量组抑制率达30%左右。结论莫诺苷可能通过影响Cox的含量抑制ADP诱导的兔血小板聚集。Objective To investigate the effect of morroniside on cycloxygenase（Cox） in the condition of platelet aggregation induced by adenosine diphosphate（ADP） in rabbits.Methods The levels of Cox induced by ADP in different groups were detected by enzyme-linked immunosorbent assay（ELISA）.Results Compared with the control group,all the morroniside groups significantly inhibited the increase of Cox induced by ADP（P0.001）,which had concentration dependence,and the inhibition rate of high dose group was 30%.Conclusion Morroniside can decrease the level of Cox and it may be the mechanism of morroniside on inhibiting the platelet aggregation induced by ADP in rabbits.

关 键 词：莫诺苷 血小板聚集 环氧酶 兔 

分 类 号：R285.5[医药卫生—中药学]