氨溴索辅助治疗小儿肺炎的临床观察  

Clinical observation of ambroxol in adjuvant therapy of infantile pneumonia

作　　者：杨杰[1] 

机构地区：[1]河南省平舆县人民医院儿科,463400

出　　处：《职业与健康》2012年第8期1011-1013,共3页Occupation and Health

摘　　要：目的评价不同途经氨溴索针剂辅助治疗小儿肺炎的临床疗效及安全性。方法将同期住院的300例肺炎患儿随机分为治疗组与对照组,每组150例。治疗组除按所感染病原的不同常规给予合理的抗感染,对症支持治疗外,均辅助氨溴索治疗,其中治疗组再随机分为氨溴索氧气驱动雾化吸入组(A组),氨溴索静脉滴注组(B组),联合应用氨溴索针剂雾化吸入及氨溴索静脉滴注组(C组);对照组仅按常规方法根据感染病原的不同给予抗感染,对症支持治疗。临床观察患儿体温恢复正常时间、咳嗽气促,喉中痰鸣缓解和肺部啰音吸收等好转情况及可能的药物不良反应,并进行住院天数比较。结果治疗组中除A、B两组患儿体温恢复正常时间与对照组无显著差异外,咳嗽消失时间,喉中痰鸣缓解,肺部啰音吸收等好转情况均优于对照组,住院天数较对照组缩短,经统计学处理,两者差异有统计学意义(P<0.05);尤其C组效果更明显(P<0.01),且临床上未发现任何明显不良反应。A、B、C 3个治疗组的总有效率均比对照组明显提高,但各治疗组之间临床疗效比较,差异并无统计学意义(P<0.05)。结论多种途径使用氨溴索针剂辅助治疗小儿肺炎均有较好疗效,联合使用氨溴索雾化吸入及静脉滴注治疗效果更显著,且安全。[Objective]To evaluate the clinical efficacy and safety of ambroxol by different administration ways in adjuvant therapy of infantile pneumonia.[Methods]300 children with pneumonia were randomly divided into the treatment group and the control group,150 cases in each group.The treatment group was given the adjuvant therapy of ambroxol on the basis of the symptomatic supportive treatment and routine anti-infection treatment according to the different pathogens.The patients in the treatment group were randomly divided into group A（toxygen atomizing inhalation）,group B（intravenous infusion） and group C（combination of inhalation and intravenous infusion）.The control group received only symptomatic supportive treatment and routine anti-infection treatment according to the different pathogens.The duration of temperature recovery,improvement of cough,gurgling with sputum and lung rale,and adverse drug reaction were observed,and the hospitalization days were compared.[Results]There was no significant difference in duration of temperature recovery between the treatment group A,the treatment group B and the control group.The duration of cough disappearance,improvement of gurgling with sputum and lung rale of the treatment group were better than those of the control group,and the hospitalization days of the treatment group were significantly shorter than those of the control group（P0.05）,and the curative effect of treatment group C more obvious（P0.01）.No obvious adverse effects were observed.The total effective rate of the treatment group A,B and C was significantly higher than that of the control group,and there was no significant difference in curative effect among three treatment groups（P0.05）.[Conclusion]Ambroxol by different administration ways shows good curative effect in adjuvant therapy of infantile pneumonia,and combination administration of inhalation and intravenous infusion has more remarkable effect and safety.

关 键 词：氨溴索 氧驱雾化 静脉点滴 小儿肺炎 

分 类 号：R725.6[医药卫生—儿科]