补充白藜芦醇对大强度运动大鼠心肌损伤的保护作用  

Protective Effects of Resveratrol on Exercise-induced Myocardial Damage in Rrats

作　　者：武胜奇[1] 张琳[2] 郝选明[2] 熊正英[3] 

机构地区：[1]广东外语艺术职业学院基础部,广州510640 [2]华南师范大学,广州510631 [3]陕西师范大学体育学院暨运动生物学研究所,西安710062

出　　处：《河南师范大学学报（自然科学版）》2012年第2期140-143,共4页Journal of Henan Normal University(Natural Science Edition)

基　　金：陕西省自然科学基金(2003C137)

摘　　要：目的:探讨RES对大强度运动心肌过氧化损伤的保护作用.方法:在活动跑台上建立大强度运动模型,测试心肌各项过氧化损伤指标.结果:大强度运动可造成大鼠心肌MDA,TNOS,iNOS,NO显著升高,TSOD,CuZn-SOD,GSH-Px,cNOS,Na+,K+-ATPase,Ca2+-ATPase显著下降.补充RES可使大鼠运动后心肌MDA,TNOS,iNOS,NO下降,TSOD,CuZn-SOD,Mn-SOD,GSH-Px,cNOS,Na+,K+-ATPase,Ca2+-ATPase升高.结论:RES可增强心肌的抗氧化能力,保持心肌酶活性.提示RES对大强度运动后心肌过氧化损伤具有保护作用.Objective：To investigate the protective effects of resveratrol on exercise-induced myocardial damage in rats. Method：Mice were trained on intensive treadmill and indicators of myocardium were detected. Results：Activities of ALT, AST, CK, LDH, ALP in levels of myocardial MDA, total NOS,iNOS,NO increased significantly in rats after intensive exer- cise; while those of myocardial total SOD, CuZn-SOD, GSH-Px, cNOS, Na＋ K＋-ATPase, CaZ＋-ATPase decreased significantly in rats after intensive exercise. The supplement of resveratrol degraded activities of ALT, AST, CK, LDH, ALP in serum and levels of myocardial MDA, total NOS,iNOS,NO after intensive exercise; while raised those of myocardial total SOD, CuZn-SOD, GSH-Px, cNOS, Na^＋ K^＋-ATPase, Ca^＋-ATPase after intensive exercise. Conclusion：The study has demonstrated that resveratrol could enhance myocardial antioxygen and enzymatic activity which suggests the protective effects of resveratrol against exerciseqnduced myocardial damage in rats.

关 键 词：白藜芦醇 大强度运动 一氧化氮 一氧化氮合酶 ATP酶 心肌 

分 类 号：G804.7[文化科学—运动人体科学]