高血压合并睡眠呼吸暂停综合征患者血压节律及心率变异的影响研究  

Investigation of the circadian rhythm and heart rate variability in hypertensive patients complicated with obstructive sleep apnea syndrome

作　　者：章琦[1] 胡立群[1] 陈莉[1] 

机构地区：[1]安徽医科大学附属省立医院干部病房,230001

出　　处：《新医学》2012年第2期90-93,共4页Journal of New Medicine

摘　　要：目的:研究阻塞性睡眠呼吸暂停综合征(OSAS)对高血压患者血压昼夜节律及心率变异性(HRV)的影响。方法:选取该科诊治的61例患者和30名健康体检人员,根据是否患有高血压及OSAS分为正常对照组、单纯高血压组、高血压合并OSAS组。比较3组之间非杓型昼夜血压曲线的比例、HRV时域指标(低频、高频)与频域指标(SDNN、PNN50)以及夜间平均血氧水平、呼吸紊乱指数(AHI)的差异。结果:高血压合并OSAS组患者呈非杓型昼夜血压曲线的比例以及HRV时域指标(低频、高频)与频域指标(SDNN、PNN50)均较其他两组明显增加(P<0.01);且夜间平均SaO2明显低于其他两组,而AHI则明显高于其他两组(P<0.01)。结论:OSAS合并高血压患者血压昼夜节律呈非杓型,HRV增强,夜间平均血氧水平下降,AHI明显增加,可能是高血压患者心血管事件增加的重要危险因素。Objective： To investigate the influence of obstructive sleep apnea syndrome（OSAS） on circadian blood pressure variability and heart rate variability（HRV） in essential hypertensive patients.Methods： A total of 92 patients were divided into three groups,normal group,pure hypertension group and hypertension complicated with OSAS group（complication group）,according the patients suffered from hypertension or/and OSAS.The rate of non-dipper day-night blood pressure curve,time-domain indexs（low frequency,high frequency）,frequency-domain indexs（SDNN、PNN50）,average night blood oxygen level,apnea-bypopnea index（AHI） were compared among three groups.Results： Compared to other groups,The rate of non-dipper day-night blood pressure curve,time-domain indexs（low frequency,high frequency）,frequency-domain indexs（SDNN、PNN50）,AHI were obviuosly higher in complication group（P0.01）,and average night blood oxygen level were obviuosly lower in complication group（P0.01）.Conclusion： The OSAS could made day-night blood pressure curve to non-dipper,HRV enhanced,average night blood oxygen level descended,AHI increased.So the OSAS was inportant risk factor to adverse cardiac events of essential hypertensive patients.

关 键 词：阻塞性睡眠呼吸暂停综合征 高血压 血压昼夜节律 心率变异性 

分 类 号：R544.1[医药卫生—心血管疾病]