大鼠新颖寻求特质与冲动性行为的关系  

Relationship between novelty seeking phenotype and impulsive behavior in rats

作　　者：张文婷[1] 张柳[1] 李新旺[1] 

机构地区：[1]首都师范大学心理系,北京100089

出　　处：《中华行为医学与脑科学杂志》2012年第4期321-323,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：教育部人文社会科学规划基金项目（IOYJAXLX010）

摘　　要：目的考察大鼠新颖寻求特质与冲动性行为是否存在相关。方法采用新颖环境自发活动模型和新颖客体偏爱模型测量大鼠新颖寻求特质，采用延迟折扣模型测量大鼠冲动性；通过计算相关系数，考察这两种特质之间的关系。结果新颖环境30min水平运动量为（4695．58±1579．87）cm，新颖客体探索次数为（20．92±14．84）次和探索时间为（178．12±135．22）S。冲动性测试2d大鼠选择低额奖赏端（LR）的次数的平均值为（4．71±2．71）次。相关分析结果显示，在新颖客体偏爱指标上，新颖客体探索时间与冲动性之间的相关达到显著水平（r=0．295，P〈0．05）；而新颖环境自发活动量与冲动性不相关。结论大鼠新颖需求特质与冲动性行为存在一定程度的相关，但这种相关与测量模型之间存在交互作用。Objective To investigate the relationship between novelty seeking and impulsivity behavior in rats. Methods Two models were used to test Novelty seeking,one was activity in a new environment model, the other was novel object preference model. And impulsivity was measured by T-maze. All rats（48） were used to ex- amine the relationship between these two behaviour traits. Results Novelty seeking：the locomotor activities meas- ured in a new environment for 30 min were （4695.58 ± 1579.87） cm,the exploring number of entries into the no- vel object area and time spending in the novel object area were respectively（20.92 ± 14.84）entries and （178.12 ± 135.22 ） s . hnpulsivity ： the average times of choosing low reward （LR） in the two test days were （ 4.71±2.71 ）. Pearson product moment correlation was performed to investigate the relationship between these two behaviour traits ,and the results suggested that there were notable correlation between novel object preference and impulsive deci- sion making（ r = 0. 295, P〈 0.05 ） ,yet no significance were found between new environment activity and impulsive decision making. Conclusion Novelty seeking and impulsivity may be correlated with each other depending on different models.

关 键 词：新颖寻求 冲动性 T迷宫 

分 类 号：R181.39[医药卫生—流行病学]