家兔扣带回前部痛单位的电活动及其受体机制  

Electric Activity of the Pain Units of the Anterior Cingulate Cortex and Its Receptor Mechanism in Rabbits

作　　者：莫书荣[1] 黄忠致[1] 

机构地区：[1]广西医科大学针刺镇痛研究室,南宁530021

出　　处：《针刺研究》2000年第1期14-17,共4页Acupuncture Research

摘　　要：用玻璃微电极记录方法在清醒麻痹的家兔上探讨扣带回前部 (ACC)痛单位的电活动及其对外周伤害性刺激反应的可能机制。结果发现 ,ACC的痛单位占引导神经元数的 9.5 % ;其中 ,痛兴奋神经元 1 2 2个 ,占痛单位的 81 .3 % ;痛抑制神经元 2 8个 ,占痛单位的 1 8.7%。除对照组外 ,大多数痛单位对伤害性刺激的痛反应均明显受受体拮抗剂或激动剂如酚妥拉明、氟哌啶醇、阿托品、地西泮、赛庚啶等的影响。提示 :扣带回前部参与痛信息的管理 ;外周神经及中枢许多相关核团可能通过去甲肾上腺素、多巴胺、乙酰胆碱、γ 氨基丁酸、5This study using the micro electrode recording method investigated the electric activity of the pain units of the anterior cingulate cortex (ACC) and its response mechanism to peripheral noxious stimulation in conscious paralytic rabbits. The results showed∶ the pain units of ACC amounted to 9.5% of the neurons recorded; among them, PEN was 122 and PIN, 28. The pain response of the most pain units to peripheral noxious stimulation was affected apparently by phentolamine, haloperidol, atropine, diazepam, cyproheptadine. The data demonstrate that ACC participates in the management of pain; peripheral nerve and many central nuclei may modulate the electric activity of the pain units of the ACC through norepinephrine, dopamine, acetylcholine, γ amino butyric acid, 5 hydroxytryptamine or histamine and its receptors.

关 键 词：痛单位 扣带回前部 酚妥拉明 氟哌啶酶 针刺镇痛 

分 类 号：R246.2[医药卫生—针灸推拿学]