针刺对糖尿病大鼠坐骨神经中cAMP、cGMP含量的影响  

Acupuncture Therapy Prevents the Decrease of the Content of cAMP and cGMP of the Sciatic Nerve in the Diabetic Rat

作　　者：王昕[1] 王宏才[1] 田德全[1] 陈丁生[1] 朱丽霞[1] 

机构地区：[1]中国中医研究院针灸研究所,北京100700

出　　处：《针刺研究》2000年第1期34-37,共4页Acupuncture Research

基　　金：国家自然科学基金!(No.39770 92 6 )

摘　　要：本实验采用链脲佐菌素 (STZ)诱发大鼠实验性糖尿病 ,以坐骨神经中cAMP、cGMP作为检测手段 ,观察了针刺对糖尿病大鼠的治疗作用。结果显示 ,糖尿病大鼠 (DM)坐骨神经中cAMP、cGMP含量明显低于正常大鼠 (ND) (P <0 .0 1 ) ,而给予STZ糖尿病大鼠针刺治疗 4个月后 ,针刺治疗组 (Ac)坐骨神经中cAMP、cGMP含量与造模组比较有明显差异 (P <0 .0 1 )。提示针刺可防止糖尿病大鼠坐骨神经中cAMP、cGMP含量的下降 。Intra peritoneal administration of streptozotoxin(STZ) produced diabetes in the Wistar rats. One week after STZ injection the animals were considered to be diabetic rats if the contents of their blood glucose were higher than 16.7 mmol/L.Then the diabetic rats were randomly divided into two groups,diabetic group (DM) without any treatment and acupuncture group (Ac) treated with acupuncture. Four months after treatment the animals were sacrificed and their sciatic nerves were taken out for cAMP and cGMP detection. The concentrations of cAMP and cGMP in the sciatic nerve of rats in DM group were significantly lower than those in age matched non diabetic group (ND) and Ac group (P<0.01, respectively). There was no significant difference between ND and Ac group. The results suggested that acupuncture therapy might prevent the decrease of the contents of cAMP and cGMP in the diabetic sciatic nerve.

关 键 词：针刺 链脲佐菌素 糖尿病 CAMP CGMP 坐骨神经 

分 类 号：R246.1[医药卫生—针灸推拿学] R246.6[医药卫生—中医临床基础]