艾灸结合免疫调节剂对肿瘤细胞c-erbB-2mRNA表达的影响  

Effect of Moxibustion Combined with Immunomodulator on Expression of c-erbB-2 mRNA

作　　者：裴建[1] 陈汉平[2] 赵粹英[2] 蒋惠秋[3] 钱连芳[3] 

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海市针灸经络研究所,上海200032 [3]上海市肿瘤研究所,上海200032

出　　处：《针刺研究》2000年第1期43-45,共3页Acupuncture Research

基　　金：国家自然科学基金!(No .395 70 882 ) ;上海市卫生局科研课题资助

摘　　要：用Northern印迹分析艾灸结合免疫调节剂抑制肿瘤细胞增殖的机制。结果显示 ,艾灸及其结合免疫调节剂可明显降低c erbB 2mRNA的表达水平。表明艾灸及其结合免疫调节剂抑制肿瘤细胞增殖 ,可能与下调c erbB 2基因转录水平 。Molecular biological mechanism of the action of moxibustion combined with immunomodulator was investigated, using the mice which were subcutaneously transplanted with H 22 (Haptoma) cell line as a solid carcinoma model. The result showed that c erbB 2 mRNA expression level was obviously reduced in tumor tissue in moxibustion group and group moxibustion and immunomodulator combination(group M+IM),as compared with tumor control group. The result implied that inhibition of tumor cell proliferation by moxibustion and immunomodulator combination was related to the reduction of c erbB 2 mRNA through decreasing rates of c erbB 2 gene transcription.

关 键 词：艾灸 免疫调节剂 肿瘤细胞 C-ERBB-2 MRNA 

分 类 号：R245.81[医药卫生—针灸推拿学] R246.5[医药卫生—中医临床基础]