北方地区蝮蛇咬伤致DIC样综合征的临床研究  

Clinical research on DIC-like syndrome induced by agkistrodon halys bites in north china

作　　者：张建波[1] 闫乐媛[1] 孙荣距[1] 苏琴[1] 秦宇红[1] 张宪[1] 党伟[1] 赵志国 赵晓东[1] 

机构地区：[1]解放军总医院第一附属医院急救部,北京100048 [2]山东省聊城市东昌府区人民医院急诊科

出　　处：《临床急诊杂志》2012年第2期80-82,85,共4页Journal of Clinical Emergency

基　　金：国家自然科学基金(No:30700869)

摘　　要：目的:探讨北方地区蝮蛇咬伤引起DIC样综合征的临床表现及预后情况。方法:对2010-06-2011-09来本院就诊的97例蝮蛇咬伤病例进行回顾性分析,对其中确诊为DIC样综合征的9例病例进行血小板计数及凝血系统指标D-二聚体、血浆凝血酶原时间、活化部分凝血活酶时间、血浆纤维蛋白原及凝血酶时间检测及分析。结果:北方地区蝮蛇咬伤后DIC样综合征的发生率约为9.3%;9例患者分别于伤后1～8d内出现DIC现象,持续时间约2～7d,均无临床DIC表现。结论:北方地区蝮蛇咬伤可引起患者凝血及纤溶系统异常,出现DIC样综合征。Objective：To explore the clinical manifestations and prognosis of DIC-like syndrome induced by Agkistrodon Halys bites in north China.Method：97 Agkistrodon Halys bites cases adopted in our hospital between June 2010 and September 2011 were retrospectively analyzed,and 9 cases with confirmed diagnosis of DIC-like syndrome were taken blood samples to measure platelet counts（PLT） and indicators of coagulation system such as D-Dimer,prothrombin time（PT）,activated partial thromboplastin time（APTT）,fibrinogen concentration（Fg） and thrombin time（TT）.Result：The incidence of DIC-like syndrome induced by Agkistrodon Halys bites in north China was about 9.3%;DIC was investigated in the 9 cases at 1 to 8 days after injury,with a duration of 2 to 7 days and no clinical DIC manifestation.Conclusion：Agkistrodon Halys bites in north China can induce abnormal coagulation and fibrinolysis in the patients,and lead to DIC-like syndrome.

关 键 词：蛇咬伤 DIC样综合征 北方地区 蝮蛇 

分 类 号：R646[医药卫生—外科学]