Synthesis of novel chiral tetraaza ligands and their application in enantioselective transfer hydrogenation of ketones  

作　　者：Shen Luan Yu Yan Yun Li Zhen Rong Dong Jing Xing Gao 

机构地区：[1]State Key Laboratory of Physical Chemistry of Solid Surfaces,National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters and Department of Chemistry,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China

出　　处：《Chinese Chemical Letters》2012年第4期395-398,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.20423002,20923004,and 21173176);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT1036);State Key Laboratory of Physical Chemistry of Solid Surfaces for financial support

摘　　要：Novel chiral tetraaza ligands（R）-N,N′-bis[2-（piperidin-1-yl）benzylidene]propane-l,2-diamine 6 and（S）-N-[2-（piperidin-l- yl）benzylidene]-3-{[2-（piperidin-1-yl）benzylidene]amino}-alanine sodium salt 7 have been synthesized and fully characterized by NMR,IR,MS and CD spectra.The catalytic property of the ligands was investigated in Ir-catalyzed enantioselective transfer hydrogenation of ketones.The corresponding optical active alcohols were obtained with high yields and moderate ees under mild reaction conditions.Novel chiral tetraaza ligands（R）-N,N′-bis[2-（piperidin-1-yl）benzylidene]propane-l,2-diamine 6 and（S）-N-[2-（piperidin-l- yl）benzylidene]-3-{[2-（piperidin-1-yl）benzylidene]amino}-alanine sodium salt 7 have been synthesized and fully characterized by NMR,IR,MS and CD spectra.The catalytic property of the ligands was investigated in Ir-catalyzed enantioselective transfer hydrogenation of ketones.The corresponding optical active alcohols were obtained with high yields and moderate ees under mild reaction conditions.

关 键 词：Asymmetric catalysis INDIUM KETONES Tetraaza ligand Asymmetric transfer hydrogenation 

分 类 号：O641.4[理学—物理化学] TQ463.53[理学—化学]